I'm thrilled to bring you this conversation about a breakthrough in male fertility diagnostics that's been literally hiding in plain site. In this episode, I'm joined by Dr. Jeff Lysiak, PhD, co-founder and Chief Science Officer at PS Fertility, to discuss phosphatidylserine (PS) and how this critical molecule on sperm is revolutionizing how we diagnose male infertility. Jeff shares the fascinating story of how his research at the University of Virginia led to discovering that PS on the surface of sperm is essential for fertilization and how traditional semen analysis completely misses this vital piece of the puzzle.
Read the full show notes on my website.
This episode addresses a frustration I've experienced for years in my practice: couples with "normal" semen analysis results who still have trouble when it comes to trying to conceive. Research shows that 20-30% of men with normal basic semen analysis could still be infertile, and we've had no way to identify them, until now.
In this episode, we cover:
What phosphatidylserine (PS) is and why it's critical for sperm to fuse with and fertilize an egg
The major limitations of standard semen analysis (count, motility, morphology) and why 20-30% of men with "normal" results may still be infertile
How the PS Detect test works using flow cytometry to assess over 10,000 sperm per sample
The connection between varicocele and low PS scores—and how varicocelectomy surgery can restore PS levels to normal ranges
When the PS test should be ordered in a fertility workup and what to do if scores are low
Early data showing over 30% of men seeking fertility treatment have low PS scores, including those with normal semen analysis
How this test can prevent women from undergoing unnecessary treatments when the male factor is undiagnosed
Resources:
PS Fertility website: psfertility.com
PS Detect at-home test kit
Nature Communications publication on phosphatidylserine and fertilization
Dr. Aimee's Supplement Stack
The TUSHY Method
OVANAD+ by Theralogix. Use code EGG.
Would you like to learn more about IVF?
Click here to join Dr. Aimee for The IVF Class.
The next live class call is on Monday, April 20, 2026 at 4pm PST, where Dr. Aimee will explain IVF and there will be time to ask her your questions live on Zoom.
Dr. Aimee Eyvazzadeh is one of America's most well known fertility doctors. Her success rate at baby-making is what gives future parents hope when all hope is lost. She pioneered the TUSHY Method and BALLS Method to decrease your time to pregnancy. Learn more about the TUSHY Method and find a wealth of fertility resources at www.draimee.org.
Other ways to connect:
Subscribe to my YouTube channel for more fertility tips
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Keywords:
male infertility, phosphatidylserine, PS score, PS Detect, male fertility testing, semen analysis limitations, sperm function, fertilization competence, varicocele, unexplained infertility, IUI success rates, male factor infertility, reproductive urology, Jeff Lysiak, PS Fertility, sperm egg fusion, fertility diagnostics, at-home sperm test, idiopathic male infertility, fertility workup, egg whisperer show, Dr. Aimee
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