JAMA+ AI Conversations

AI chatbots have advanced rapidly, incorporating new reasoning architectures that reshape decision-making and medical education. Jonathan Chen, MD, PhD, and Ethan Goh, MD, MS, of Stanford University join JAMA and JAMA+ AI Associate Editor Yulin Hswen, ScD, MPH, to discuss the latest generation of AI models, the importance of evaluating benefits and harms, and sycophancy in AI systems. Related Content: Multiple Reasoning Models and the Future of AI Chatbots AI Chatbots in Clinical Practice Large Language Model Influence on Diagnostic Reasoning

JAMA+ AI Editor in Chief Roy Perlis and Associate Editor Yulin Hswen discuss some of the most cited AI papers in 2025 across the JAMA Network. A little bit of gen AI, some prediction models, and deep learning from videos as well as an increasing awareness of the challenges of real-world deployment. Related Content: AI and Health—The Year in Review

How can AI systems reason safely in the open world of medicine? JAMA+ AI Associate Editor Yulin Hswen, ScD, MPH, talks with Eric Horvitz, MD, PhD, Chief Scientific Officer at Microsoft, about the future of AI in 5 years to 100 years, from neurons to the nebulous, and how we can guide AI to be copilots while maintaining integrity and safety in the clinical arena. Related Content: AI—Days of Future Past

Will AI usher in a new era of rapid drug discovery? In this episode of JAMA+ AI Conversations, Editor in Chief Roy Perlis interviews Ajamete Kaykas, Chief eXploration Officer at Insitro, a biotech company looking to apply AI to develop new therapeutics. Related Content: AI in the Lab—Will It Really Change Drug Discovery?

Derek Angus, MD, MPH, joins JAMA+ AI Editor in Chief Roy Perlis, MD, MSc, to discuss a special communication from JAMA Summit: Artificial Intelligence. Related Content: What the Experts Think About Where AI Is Headed AI, Health, and Health Care Today and Tomorrow