Questioning Medicine

we look at CODE LVO and what does being frail even mean?????

vaccines may not help baby and antibiotics still don't help viral illness

CME song --Check the Lytes

CME - sodium, potassium, calcium

10.1016/j.jaip.2025.07.005.40675327
All of the videos were found to be useful or very useful, 99% were of moderate or high reliability, and 99% had moderate to excellent educational quality 
 Prostate-specific antigen levels among participants receiving annual testing. JAMA Oncol 2025 Nov; 11:1341 10.1001/jamaoncol.2025.3386.40965920
PSA levels at or above 4.0 ng/mL fell below that threshold on the next annual test 30% of the time.
 10.1016/S2665-9913(25)00250-4.
During 10 years of follow-up, patients in the PKA and TKA groups did not differ significantly in pain, function, or quality of life
https://www.nejm.org/doi/full/10.1056/NEJMoa2508026?query=TOC
Among patients who underwent CABG for an acute coronary syndrome, ticagrelor plus aspirin did not result in a lower incidence of death, myocardial infarction, stroke, 
https://www.nejm.org/doi/full/10.1056/NEJMoa2509907?query=TOC
In this trial, a high-dose inactivated influenza vaccine did not result in a significantly lower incidence of hospitalization for influenza or pneumonia than a standard dose among older adults. 
 
https://www.nejm.org/doi/full/10.1056/NEJMoa2509834?query=TOC
Among community-dwelling adults 65 to 79 years of age, there appeared to be fewer hospitalizations for influenza or pneumonia with high-dose inactivated influenza vaccine than with the standard dose but the NNT is like 1500!
 
https://pmc.ncbi.nlm.nih.gov/articles/PMC12594118/
Afib should not be screened even if the authors say yes
 
https://pubmed.ncbi.nlm.nih.gov/40997143/
defines the US cost-effectiveness threshold as $120 000 per quality-adjusted life year gained,
 
 https://pubmed.ncbi.nlm.nih.gov/40481660/
In CKD, electronic letter nudges for patients or primary care practices did not differ from no letters for prescriptions of guideline-recommended RASis or SGLT2is at 6 months.
 
 
https://www.clinicalkey.com/#!/content/playContent/1-s2.0-S0140673625015922?returnurl=https:%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0140673625015922%3Fshowall%3Dtrue&referrer=https:%2F%2Fclinician.nejm.org%2F
β-blocker therapy on clinical outcomes in patients with myocardial infarction and mildly reduced (40–49%) 
 
https://www.nejm.org/doi/10.1056/NEJMoa2512686#ap2&uccLastUpdatedDate=2025-12-12%2005%3A34%3A29.658%20%2B0000&rememberMe=false
In this meta-analysis including individual-patient data from five randomized trials, beta-blocker therapy did not reduce the incidence of death from any cause, myocardial infarction, or heart failure in patients with an LVEF of at least 50% after myocardial infarction without other indications for beta-blockers.

Wolfe R, Broder JC, Zhou Z, et al. Aspirin, cardiovascular events, and major bleeding in older adults: extended follow-up of the ASPREE trial. Eur Heart J. 12 Aug 2025. [Epub ahead of print]. https://pubmed.ncbi.nlm.nih.gov/40796244/
 
Donocan LE et al. Closed-loop insulin delivery in type 1 diabetes in pregnancy: The CIRCUIT randomized clinical trial. JAMA 2025 Oct 24; [e-pub]. (https://doi.org/10.1001/jama.2025.19578)
 
https://jamanetwork.com/journals/jama/fullarticle/2822766
 
https://onlinelibrary.wiley.com/doi/full/10.1002/art.24894?msockid=3f10fb6c3d086e4c32e2ede23c9e6fbc
 
https://pubmed.ncbi.nlm.nih.gov/41118187/
 
https://pubmed.ncbi.nlm.nih.gov/41115754/
 
 
https://pubmed.ncbi.nlm.nih.gov/41138956/