LONGEVITY with Nathalie Niddam

Today, I'm joined by the insightful Dr. Nafysa Parpia, a true leader in environmental and complex chronic illness medicine and the Director of Naturopathic Medicine at Gordon Medical. In our conversation, Dr. Parpia shares how her passion for deep, integrated healing brought her into the world of environmental toxins, hormone health, and the nuanced ways our bodies respond to the modern world. She opens up about her journey, the unique challenges women face—especially during menopause—and why so many aren't finding answers in traditional medicine.
 
Episode Timestamps:
Welcome & episode goals ... 00:00:00
Environmental toxins and complex illness ... 00:01:17
Rise of chronic illnesses; environmental triggers ... 00:07:26
Lead, bone loss, and menopause ... 00:10:03
Sources of lead exposure today ... 00:12:03
Chelation therapy: what, when, and how ... 00:14:26
Opening detox pathways: herbs and bioregulators ... 00:17:17
Menopause, toxic burden, and immune shifts ... 00:20:49
CDC data: multiple toxins and cumulative risk ... 00:23:02
Genetics, nutrition, and susceptibility ... 00:28:12
Personalized medicine & system constraints ... 00:30:03
Heavy metals, inflammation, and hormone effects ... 00:35:35
Peptide and bioregulator therapy: sequencing matters ... 00:41:12
Testing mistakes: over- and under-testing ... 00:57:41
Preparing for detox: the Pretox approach ... 01:02:58
Sensitivity to binders and protocol adjustments ... 01:16:50
Plasmapheresis (TPE): science and application ... 01:19:19
Optimizing menopause care and women's self-sovereignty ...  01:25:28
 
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Dr. Bill Lawrence Episode

Today, I'm joined by the legendary Dr. Jeffrey Bland, widely known as the "father of functional medicine" and a true pioneer in the science of longevity and immune resilience. In this conversation, Dr. Jeffrey Bland opens up about his decades-long journey questioning the conventional medicine model, the personal moments that shaped his mission, and how his passion for asking the right questions ultimately led him to reshape the future of healthcare.
Visit Bigboldhealth.com/NAT and get 15% off automatically at checkout.
 
Episode Timestamps:
Focus on immune system aging ... 00:00:00
Questioning conventional medicine and the roots of chronic disease ... 00:05:00
Functional medicine and influences like Linus Pauling ... 00:12:39
Dangers of oversimplification and the limits of biohacking ... 00:17:21
Evolving thinking on supplements and the power of cycling and personalization ... 00:19:37
Why immune resilience trumps immune boosting for longevity ... 00:25:21
Diet's impact on immune cell turnover and long-term health ... 00:28:57
Autoimmunity, CHIP cells, inflammaging, and biological individuality ... 00:32:04
Microbiome, mitochondria, and immune-driven fatigue ... 01:00:07
The 4R gut and immune program as a starting point ... 01:06:26
Movement, lymphatics, and rejuvenation ... 01:08:35
Food as information, epigenetics, and practical recommendations ... 01:11:25
90-day immune system renewal and rapid-fire takeaways ... 01:31:40
 
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Dr. Bill Lawrence Episode

Today, I'm joined by Dr. Aimie Apigian, an innovative leader in the biology of trauma, whose work bridges the worlds of science, medicine, and lived experience. In our conversation, Dr. Apigian opens up about her journey from conventional medicine—where symptom management was the norm—to uncovering the physiological roots of trauma and the crucial role our nervous system plays in resilience and healing. She shares how her own health struggles, her work with adopted children, and a relentless curiosity led her to re-examine everything she thought she knew about stress, autoimmunity, and capacity.
The 7-Day Somatic Healing for Stored Emotions - https://traumahealingaccelerated.mykajabi.com/a/2148170319/wdrhGYaY
21-Day Journey, a daily live session program that helps participants understand how much trauma their body may be holding - https://traumahealingaccelerated.mykajabi.com/a/2147704575/wdrhGYaY

Episode Timestamps:
Introduction, host's mission, and episode theme ... 00:00:00
Science behind trauma, limits of traditional medicine, and autoimmune experiences ... 00:06:11
Attachment, symptom management, functional medicine, and healing journey ... 00:08:17
Mold exposure, state triggers, brain inflammation, and capacity blocks ... 00:14:22
Medical gaslighting, trauma validation, and biological capacity ... 00:18:25
Safety, resilience, and chronic survival state effects ... 00:19:32
Misconceptions about chronic stress—emergency brake and vagus nerve ... 00:22:27
Attachment patterns, autoimmunity, and shrinking world ... 00:28:47
Chronic survival loop, exhaustion, coping strategies, and shutdown ... 00:31:11
Moving to repair: phases of healing and gentle approaches ... 00:34:08
Somatic practices, art therapy, and different expressions of trauma ... 00:39:01
Shifts in sleep, digestion, anxiety, and felt safety ... 00:42:06
Tracking nervous system state: strategies and awareness ... 00:46:41
Therapy limitations: biology and somatic integration ... 00:48:42
Retraining vs. managing symptoms, stabilization, and healing ... 00:54:53
Capacity, resilience, lessons from centenarians, and longevity ... 01:00:06
Trauma's impact on mitochondria, telomeres, and generational health ... 01:06:27
Gut microbiome and trauma: two-way connection ... 01:08:03
 
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Dr. Bill Lawrence Episode

Today, I'm joined by the inspiring Leslie Kenny, Oxford-based longevity expert and a living example of turning adversity into vitality. After being told at 39 that she had lupus, rheumatoid arthritis, and just five years to live, Leslie defiantly forged a new path—reversing her diagnoses, restoring her thyroid health, and even welcoming a healthy baby girl at 43. Her story is a testament to the power of questioning the status quo, honoring the wisdom within our bodies, and refusing to accept decline as inevitable.
 
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Episode Timestamps:
Welcome, show intro, and overview ... 00:00:00
Leslie Kenny's health journey and reversing disease ... 00:00:30
Biological vs. chronological age and the immune system ... 00:04:55
Impact of trauma and stress on aging ... 00:11:51
Overcoming prognosis: lifestyle and scientific interventions ... 00:18:02
Diet, tracking, and removing triggers ... 00:22:21
The overlooked importance of thyroid health ... 00:32:23
Dangers of overdoing fasting and hormesis ... 00:40:21
Autophagy basics and the cellular cleanup crew ... 00:44:06
Spermidine's role, sourcing, and supplement quality ... 01:10:19
 Optimizing longevity habits and daily routines ... 01:29:44
 
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Dr. Bill Lawrence Episode

Today, I'm joined by the extraordinary Dr. Natalie Yivgi-Ohana, a pioneering scientist whose passion for mitochondria unlocks new frontiers in longevity medicine. Our conversation truly blew my mind—Dr. Yivgi-Ohana brings decades of expertise to demystify these tiny, ancient powerhouses that fuel every cell in our bodies, impact our hormones, drive immunity, and, as it turns out, play a central role in how we age.
 
Episode Timestamps:
Welcome to the Longevity Podcast and today's focus on mitochondria ... 00:00:00
Maternal inheritance and critical functions of mitochondria ... 00:05:56
Mitochondria as energy producers and hormone regulators ... 00:07:03
Aha moments: mitochondria control life, death, and disease ... 00:08:55
Endosymbiotic theory: how mitochondria originated ... 00:10:19
Chronic disease, aging, and the connection to mitochondria ... 00:16:10
Substrate fuels: carbs, fats, and importance of metabolic flexibility ... 00:20:18
Mitochondria's control over immune system and signaling ... 00:26:39
Mitochondrial transfer: how cells share organelle "powerhouses" ... 00:32:42
Groundbreaking therapy: transplanting mitochondria for rare diseases ... 00:36:40
Expanding mitochondrial therapies to age-related diseases ... 00:42:57
Aging in women: hormones, mitochondria, and inflection points ... 00:51:00
Stem cell exhaustion and cellular renewal ... 00:52:24
Biomarkers: ways to measure mitochondrial health ... 01:03:11
Supplements, lifestyle, and emotional health for mitochondria ... 01:15:47
Medication choices and minimizing mitochondrial toxicity ... 01:24:04
 
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