LONGEVITY with Nathalie Niddam

Today, I'm joined by the wonderful Dr. Shivani Gupta, a true force in bridging ancient Ayurvedic wisdom with cutting-edge modern research on inflammation and healthy aging. She recently authored The Inflammation Code. Dr. Shivani opens up about her deeply personal motivation—from witnessing her grandfather's preventable health decline to spending years in both traditional and scientific studies, ultimately earning a PhD focused on turmeric and chronic inflammation.
For Dr. Shivani's Turmeric and sleep gummies visit https://fusionaryformulas.com/?sca_ref=9671225.dtSyos3QQx1c and use code NAT15 for 15% off.
 
Episode Timestamps:
Welcome & Introduction to Longevity Podcast ... 00:00:00
Autophagy & Spermidine Supplementation ... 00:02:41
Personal Connection & Product Experience ... 00:03:46
Health Declines in Modern Indian Culture ... 00:07:47
Reversing Disease: Ayurveda & Biohacking ... 00:11:11
Discovering Ayurveda & Turmeric's Power ... 00:15:12
Turmeric vs. NSAIDs: Scientific Support ... 00:19:52
PPIs, Gut Health, and Curcumin ... 00:21:26
Inflammation as the Root of Chronic Disease ... 00:23:24
Sleep Rituals & Circadian Timing ... 00:28:59
Elemental Design / Doshas Explained ... 00:32:13
Aligning Lifestyle with Dosha for Health ... 00:42:46
Mental Inflammation: Stress & Burnout ... 00:46:00
Turmeric Science, Uses & Myths ... 00:54:20
Personalized Spice Use & Dosha Guidance ... 01:03:48
Top Spices for Longevity ... 01:07:44
Cautions: Medications & Turmeric ... 01:10:03
The Future of Inflammation in Medicine ... 01:11:11
Rapid-Fire Longevity Habits ... 01:15:03
 
Our Amazing Sponsors:
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Today, I'm joined by the inspiring Dr. Jeffrey Gladden—a trailblazer in longevity medicine who once spent decades as an interventional cardiologist, only to challenge everything he knew after his own health hit a wall. Dr. Gladden opens up about the moment he refused to accept "normal for your age" as a diagnosis, launching himself into the world of functional and age-management medicine to reclaim his vitality and help others do the same.
 
Episode Timestamps:
Welcome and episode introduction ... 00:00:00
Health crisis and discovering personal optimization ... 00:07:05
From "sick care" to health optimization ... 00:10:46
Vision for personalized, youthful longevity ... 00:12:17
Personalized medicine: why one size doesn't fit all ... 00:16:00
Linear versus exponential aging; fixing a flawed approach ... 00:18:02
Five circles of exponential health: key longevity domains ... 00:19:23
Curiosity, growth mindset, and quantum thinking in longevity ... 00:22:22
Why individualization is crucial for diet and interventions ... 00:28:52
Insulin resistance: the hidden driver of aging ... 00:33:41
Environmental and internal (psychospiritual) factors in health ... 00:38:40
Healing through meditation, stress management, and flow ... 00:41:15
Robustness, resilience, and anti-fragility as longevity superpowers ... 00:57:09
Safe, personalized hormone therapy and the importance of tracking ... 01:03:33
Integrating mindset, purpose, and psycho-spiritual work ... 01:08:50
Peptides and advanced therapies: preparing for optimal results ... 01:09:56
Common test misconceptions in longevity medicine ... 01:12:56
Debunking the myth of single biological age ... 01:16:38
Resources, connect with Dr. Gladden, and closing ... 01:18:09
 
Our Amazing Sponsors:
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Today, I'm sitting down with Dr. Gus Vickery, a good friend and one of my favorite collaborators when it comes to cutting-edge insights in personalized health and longevity. In this episode, I put myself under the microscope as we walk through my own metabolomics testing after a period of heavy travel, stress, and—yes—a break from my usual supplement routine. If you've ever wondered whether skipping your foundational health habits "just for a little while" really matters, you're about to find out.

If you are a clinician and would like to offer the Aristotle test to your patients please use this link to learn more about the Theriome test: therio.me/niddam 
If you are a patient and would like to run the Theriome Aristotle test and get a full interpretation and protocol based on your results from Dr Vickery & his team please use this link: https://authentichealth.com/precision-health-evaluation/
 
Episode Timestamps:
Introduction to Longevity Podcast and episode overview ... 00:00:00
Metabolomics and interpreting health data – practitioner guidance needed ... 00:05:05
Combining metabolomics, gut, and blood data for whole-system insights ... 00:06:02
Nutrient depletion and oxidative stress: critical findings ... 00:18:57
Supplementation essentials for aging well ... 00:27:05
Metabolomics comparison by age group and optimization goals ... 00:29:03
Stacking interventions: why less is more with diagnostics ... 00:31:05
Functional health markers and the value of context ... 00:34:47
Sympathetic dominance, mindset, and impact on longevity ... 00:35:26
Restoring nervous system balance – inner work and tech tools ... 00:42:38
Toxins, heavy metals, and practical detox strategies ... 00:49:11
Clean environment, resiliency, and realistic lifestyle shifts ... 00:55:29
Key nutrient deficiencies revealed by metabolomics ... 01:09:15
Genetic and metabolomic tests: what's actionable? ... 01:15:07
Hope for the future: human resilience and expanding technology ... 01:22:24
Weekly actionable: walk outside for mitochondria and stress relief ... 01:26:55
 
Our Amazing Sponsors:
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Nature's Marvels Bioregulators - provide gentle, organ-specific support — and the Liver Bioregulator is a favorite this season for supporting detox pathways and metabolic flow. Head to profound-health.com and use code NAT15 for 15% off your first order.

Blue Peptide Spray from Young Goose brings the message back loud and clear. With NAD+ APEX to refuel energy, methylene blue to recharge your mitochondria, and GHK-Cu to tell your skin, "Hey, start making that collagen again!" It's longevity science, not cosmetic hype. Visit YoungGoose.com—use code NAT10 to get started, or 5NAT if you're an existing customer.
 
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Today, I'm joined by the remarkable Dr. Gabrielle Lyon, a pioneer in redefining the longevity conversation by making muscle health—not weight—the centerpiece of aging well. With a background in geriatrics and nutritional sciences, she illuminates why the quality of your muscle tissue is a far more powerful predictor of health than any number on the scale. Her perspective challenges the notion of a "healthy sedentary person" and reveals the major role of intramuscular fat in metabolic dysfunction. Check out her book The Forever Strong Playbook. 
 
Episode Timestamps:
Introduction, podcast focus, and welcoming Dr. Gabrielle Lyon ... 00:00:00
Muscle's impact on brain health, inflammation, and healthy aging ... 00:01:03
Dr. Lyon's childhood, grit, and self-discipline ... 00:04:33
Mentorship and protein science under Dr. Donald Lehman ... 00:07:05
Muscle as the overlooked metabolic organ ... 00:08:45
Why intramuscular fat matters more than body weight ... 00:10:06
Plant vs. animal protein for muscle health ... 00:13:29
Muscle as an endocrine organ and cognition ... 00:16:21
Future of muscle science: anabolics, imaging, and technology ... 00:18:22
GLP-1s, sarcopenic obesity, and muscle-first protocol ... 00:46:45
Sarcopenia, aging, and the importance of early training ... 01:04:35
Building lifelong resilience—mental and physical ... 01:08:31
Predictions: anabolics, muscle testing, and assessment ... 01:12:17
"Strength is a responsibility, not a luxury" ... 01:13:53
 
Our Amazing Sponsors:
Cozy Earth – Thoughtfully designed bedding and bath essentials that turn your home into a calm, elevated retreat and actually hold up wash after wash. Give your space a reset at cozyearth.com with code LONGEVITY for up to 20% off, and don't forget to mention this podcast in the post-purchase survey.
 
Ozlo - use smart sound engineering and sleep detection to help you stay in deeper, more stable sleep all night. Create your ideal sleep environment anywhere: go to ozlosleep.com/nat and use code NAT to get $75 off.

Tranq Dart by Wizard Sciences - a multi-pathway sleep support from Wizard Sciences. It's not a knockout pill; it's a gentle nudge toward that wind-down zone. I take it about 30 minutes before bed, and it helps my body and brain sync up for sleep. Visit wizardsciences.com and use code NAT15 for 15% off. Sleep smarter, not harder.
 
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Today, I'm joined by the incredible Anthony Castore, a trailblazer who fuses elite strength coaching with deep cellular medicine. In our conversation, Anthony shares his journey from a young athlete determined to defy genetic odds to becoming an expert in both physical training and the nuanced science of peptides, mitochondria, and bioregulators.
 
Use code NAT10 for 10% off products at https://alchemiqlabs.com/
 
Episode Timestamps:
Welcome and episode introduction ... 00:00:00
Anthony Castore's path from strength coaching to cellular medicine ... 00:05:55
Connecting strength training with cellular pathways (AMPK, mTOR) ... 00:12:27
Explaining and balancing AMPK and mTOR for performance ... 00:13:03
Training strategies: Metabolic, hypertrophy, and neural approaches ... 00:18:18
Building a solid foundation: Lifestyle, training, nutrition, peptides ... 00:23:04
Assessing recovery capacity and individualizing protocols ... 00:26:02
Mitochondrial fission, fusion, and targeted adaptation ... 00:29:57
Optimizing muscle gain and fat loss through calories and recovery ... 00:31:00
Differentiating bodybuilder vs. longevity approaches ... 00:34:44
Integrating peptides and support molecules into routines ... 00:40:44
Ketone esters and mitochondrial peptide interventions ... 00:41:20
Cautions on stacking and combining interventions ... 00:54:04
Lessons learned from overdoing interventions ... 01:05:02
 
Our Amazing Sponsors:
Vitali - combines pharmaceutical-grade copper peptides with zero-age exosomes to support clearer cellular signaling and long-term skin resilience, working with your biology instead of forcing change. Visit VitaliSkincare.com and use code NAT20 for 20% off.
 
BEAM Minerals - Low energy often starts in the mitochondria. Support cellular energy with a bioavailable liquid mineral supplement — and get 20% off at beamminerals.com with code NAT20.
 
Complete Liver Complex by LVLUP Health - supports your liver's natural detox pathways so your body can reset after the holidays without suffering. Go to lvluphealth.com and use code NAT for 20% off.
 
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