LONGEVITY with Nathalie Niddam

Today, I'm joined by the remarkable Dr. Gabrielle Lyon, a pioneer in redefining the longevity conversation by making muscle health—not weight—the centerpiece of aging well. With a background in geriatrics and nutritional sciences, she illuminates why the quality of your muscle tissue is a far more powerful predictor of health than any number on the scale. Her perspective challenges the notion of a "healthy sedentary person" and reveals the major role of intramuscular fat in metabolic dysfunction.
 
Episode Timestamps:
Introduction, podcast focus, and welcoming Dr. Gabrielle Lyon ... 00:00:00
Muscle's impact on brain health, inflammation, and healthy aging ... 00:01:03
Dr. Lyon's childhood, grit, and self-discipline ... 00:04:33
Mentorship and protein science under Dr. Donald Lehman ... 00:07:05
Muscle as the overlooked metabolic organ ... 00:08:45
Why intramuscular fat matters more than body weight ... 00:10:06
Plant vs. animal protein for muscle health ... 00:13:29
Muscle as an endocrine organ and cognition ... 00:16:21
Future of muscle science: anabolics, imaging, and technology ... 00:18:22
GLP-1s, sarcopenic obesity, and muscle-first protocol ... 00:46:45
Sarcopenia, aging, and the importance of early training ... 01:04:35
Building lifelong resilience—mental and physical ... 01:08:31
Predictions: anabolics, muscle testing, and assessment ... 01:12:17
"Strength is a responsibility, not a luxury" ... 01:13:53
 
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Tranq Dart by Wizard Sciences - a multi-pathway sleep support from Wizard Sciences. It's not a knockout pill; it's a gentle nudge toward that wind-down zone. I take it about 30 minutes before bed, and it helps my body and brain sync up for sleep. Visit wizardsciences.com and use code NAT15 for 15% off. Sleep smarter, not harder.
 
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Today, I'm joined by the incredible Anthony Castore, a trailblazer who fuses elite strength coaching with deep cellular medicine. In our conversation, Anthony shares his journey from a young athlete determined to defy genetic odds to becoming an expert in both physical training and the nuanced science of peptides, mitochondria, and bioregulators.
 
Use code NAT10 for 10% off products at https://alchemiqlabs.com/
 
Episode Timestamps:
Welcome and episode introduction ... 00:00:00
Anthony Castore's path from strength coaching to cellular medicine ... 00:05:55
Connecting strength training with cellular pathways (AMPK, mTOR) ... 00:12:27
Explaining and balancing AMPK and mTOR for performance ... 00:13:03
Training strategies: Metabolic, hypertrophy, and neural approaches ... 00:18:18
Building a solid foundation: Lifestyle, training, nutrition, peptides ... 00:23:04
Assessing recovery capacity and individualizing protocols ... 00:26:02
Mitochondrial fission, fusion, and targeted adaptation ... 00:29:57
Optimizing muscle gain and fat loss through calories and recovery ... 00:31:00
Differentiating bodybuilder vs. longevity approaches ... 00:34:44
Integrating peptides and support molecules into routines ... 00:40:44
Ketone esters and mitochondrial peptide interventions ... 00:41:20
Cautions on stacking and combining interventions ... 00:54:04
Lessons learned from overdoing interventions ... 01:05:02
 
Our Amazing Sponsors:
Vitali - combines pharmaceutical-grade copper peptides with zero-age exosomes to support clearer cellular signaling and long-term skin resilience, working with your biology instead of forcing change. Visit VitaliSkincare.com and use code NAT20 for 20% off.
 
BEAM Minerals - Low energy often starts in the mitochondria. Support cellular energy with a bioavailable liquid mineral supplement — and get 20% off at beamminerals.com with code NAT20.
 
Complete Liver Complex by LVLUP Health - supports your liver's natural detox pathways so your body can reset after the holidays without suffering. Go to lvluphealth.com and use code NAT for 20% off.
 
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Today, I'm joined by the deeply thoughtful and refreshingly honest Dr. Sanjay Bhojraj, a self-described "curious cardiologist" who spent decades treating heart attacks in the cath lab — before stepping away to ask a bigger question: Why are we waiting for the crisis instead of preventing it?
 
Episode Timestamps:
Welcome to Longevity & episode setup … 00:00:00
Dr. Bhojraj's shift from ER cardiology to prevention … 00:06:30
Why most heart attacks aren't caused by big blockages … 00:09:15
Stress, nervous system load & heart attack risk … 00:13:10
CIMT explained: what it measures (and what it misses) … 00:26:40
Calcium scores vs CT angiograms … 00:35:45
CLEERLY scan: seeing dangerous soft plaque … 00:38:45
Can plaque actually regress? … 00:41:55
When heart scans make patients less afraid … 00:44:05
When should you test — even without symptoms? … 00:45:50
Why age 45 is a major cardiovascular inflection point … 00:47:10
Hormones, estrogen loss & women's heart risk … 00:50:10
Why cardiology still misunderstands women … 00:54:30
Small dense LDL, ApoB & oxidized cholesterol … 01:02:00
Why fixing inflammation matters more than numbers … 01:05:50
 
Our Amazing Sponsors:
Regenerive - Built around clinically validated Longufera (Ash X4) to support core aging pathways—so it's not just "healthy aging" in theory. Go to regenerive.co and use code NAT25 to save 25%
 
Mitopure® Longevity Gummies are the only clinically proven Urolithin A gummies supporting mitochondrial health — one of the key hallmarks of aging. Get 35% off a one-month subscription at Timeline.com/Nat2026 *Special deal through January 2026.
 
PW1 by Puori — A clean, high-quality whey protein that's third-party tested for over 200 contaminants and smooth enough to feel like a treat while supporting muscle, metabolism, and bone strength. Go to puori.com/NAT and use code NAT for 32% off your first subscription or 20% off anything on the site.
 
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Today, I'm joined by Charles Bohdy, a true innovator in water purification technology, and Victor Sagalovsky, a passionate advocate for bringing the science of water quality into our daily lives. Together, we take a deep dive into the unseen world of the water running through our homes—exploring not just its purity, but its hidden potential to support our biology in ways most of us have never considered.
Whole HOME Water System - Use code NAT100
 
Episode Timestamps:
Intro to Longevity Podcast and today's water focus ... 00:00:00
Water system's health benefits and testing ... 00:01:33
Why water quality is overlooked yet critical ... 00:07:20
Common water issues and municipal limitations ... 00:09:10
Filtration methods: carbon blocks and pathogens ... 00:15:26
Charles's nano-ceramic multilayer filters ... 00:20:14
Concerns with chlorine and fluoride in water ... 00:23:44
Retaining healthy minerals: charge-based filtration ... 00:35:18
Reverse osmosis: pros, cons, and fungal risks ... 00:50:49
Structured water's role in biological health ... 00:56:53
Water structuring: agricultural validation ... 01:00:21
Whole-home filtration: installation and costs ... 01:11:02
Closing thoughts: bringing nature's water home ... 01:25:00
 
Our Amazing Sponsors:
Regenerive - Built around clinically validated Longufera (Ash X4) to support core aging pathways—so it's not just "healthy aging" in theory. Go to regenerive.co and use code NAT25 to save 25% 
Primeadine by Oxford Healthspan: Primeadine supports autophagy — your cells' natural renewal and cleanup process — using food-derived spermidine, no fasting required. If you want to support resilience from the inside out, head to https://www.oxfordhealthspan.com/BIONAT20 and use code BIONAT20 at checkout (one-time purchases only).
Ozlo - use smart sound engineering and sleep detection to help you stay in deeper, more stable sleep all night. Create your ideal sleep environment anywhere: go to ozlosleep.com/nat and use code NAT to get $75 off.
 
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Today, I'm joined by Ben Katz—better known online as Mr. Mass Spec —an academic analytical chemist from UC Irvine whose mission is to uncover what's really in our everyday foods, drinks, and products. Ben reverse engineers everything from Taco Bell meat to Doritos, and sometimes even entire industries, using cutting-edge mass spectrometry. His curiosity and expertise have made him a go-to source for those wanting to know what's hiding behind vague ingredient labels and "natural flavors."
 
Episode Timestamps:
Welcome and podcast introduction ... 00:00:00
What is mass spectrometry? ... 00:05:00
Viral "what's in it?" projects and public interest ... 00:07:27
Synthetic vs. plant-derived nicotine and toxins in plant extracts ... 00:09:53
Food label transparency and loopholes (natural flavors, FEMA, GRAS) ... 00:20:11
Sweeteners & artificial additives: sucralose, stevia, cost motivations ... 00:23:07
Ultra pasteurization of milk and added flavors ... 00:29:48
Chocolate, caffeine content, and labeling challenges ... 00:33:12
Industrial food processes, GMOs, and food security insights ... 00:38:36
Microplastics: occurrence, regulation, and PEG in food ... 00:50:15
Supplements under development for microplastic removal ... 00:58:43
Adulteration in olive oil, maple syrup, and honey ... 01:04:08
Hidden sweeteners, and processed food pitfalls ... 01:10:14
Avoid artificial sweeteners, problematic plastics, and hidden flavors ... 01:14:36
 
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Manukora Honey - rich, creamy Manuka honey packed with powerful bioactives, all in just one heaped teaspoon a day. Go to MANUKORA.com/NAT to save up to 31% plus $25 in free gifts with the Starter Kit.

 
Magnesium Breakthrough - uses seven absorbable forms of magnesium to support deeper sleep, calmer nerves, and real recovery. Get up to 35% off at bioptimizers.com/bionat with code BIONAT.
 
Nature's Marvels Bioregulators - provide gentle, organ-specific support — and the Liver Bioregulator is a favorite this season for supporting detox pathways and metabolic flow. Head to profound-health.com and use code NAT15 for 15% off your first order.
 
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