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The Human Upgrade: Biohacking for Longevity & Performance

Dave Asprey
The Human Upgrade: Biohacking for Longevity & Performance
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  • The Human Upgrade: Biohacking for Longevity & Performance

    The Real Reason She Loses Interest in Sex | John Gray : 1465

    12/05/2026 | 1 h 14 min
    The person you love is either raising your hormones or destroying them, and most people have no idea which one is happening to them. John Gray, the author of one of the most beloved relationship books of all time, returns to reveal how your relational environment directly shapes your biology, and what you can do right now to hack it.

    Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR

    John Gray wrote Men Are from Mars, Women Are from Venus, the number one bestselling book of the entire decade and one of USA Today's top 10 most influential books of the last quarter century. His books have been translated into 45 languages across more than 100 countries. But what most people miss is that Gray is also a pioneer in the intersection of hormonal health, brain optimization, and human performance, a biohacker before the word existed. His newest book, Men Are from Mars for Women Only: Be Happy With or Without a Man, is the first in a six-part series packed with cutting-edge insights on relationships, biology, and longevity.

    Host Dave Asprey and John Gray go deep on the hormonal mechanics of desire, attraction, and emotional regulation, covering why societal testosterone collapse is driving relationship breakdown, how estrogen and testosterone function as a polarity system in both men and women, and why the relational environment you create every day is either building or destroying your biological potential. They also cover lithium orotate as a brain optimization supplement, the anti-aging power of semen retention, pre-digested protein as a nootropics-adjacent tool for brain healing, and how fasting and discipline directly boost testosterone. Gray even shares how he reversed early-stage Parkinson's using biohacking techniques and now maintains a testosterone level of 600 at age 74, with zero pharmaceutical support.

    This is essential listening for anyone serious about biohacking, longevity, anti-aging, supplements, human performance, brain optimization, functional medicine, metabolism, and hacking the biology of love and attraction.

    You'll Learn:
    Why testosterone collapse is the hidden driver behind modern relationship failure
    How your partner's emotional state directly affects your hormones in real time
    The prolactin trap that kills sexual desire in long-term relationships and how to escape it
    Why lithium orotate is one of the most underrated supplements for dopamine and serotonin balance
    How mirror neurons open and close based on stress, and what that means for emotional connection
    The five-finger ask technique that raises estrogen and testosterone simultaneously
    How pre-digesting protein with enzymes achieves 93 percent assimilation and supports brain repair
    Why fasting, discipline, and semen retention are among the most powerful testosterone-building tools available

    Thank you to our sponsors!
    - Active Skin Repair | Get 25% off your order until May 21, after that, it drops back to 20%, visit ActiveSkinRepair.com and use code DAVE. You can also find Active Skin Repair on Amazon and at your local CVS
    - iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE
    - Amp | If you're ready to make fitness fit into your life, go to amp.ai to check it out
    - Igniton | Try risk free at Igniton.com and use code DAVE at checkout for 15% off. Backed by a 30-day money back guarantee.
    - Pique | Go to Piquelife.com/dave for 20% off

    Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.

    New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.

    Keywords: John Gray, Men Are from Mars Women Are from Venus, testosterone, estrogen, hormonal health, hormone optimization, prolactin, oxytocin, dopamine, serotonin, lithium orotate, mirror neurons, longevity, anti-aging, biohacking, supplements, fasting, semen retention, NoFap, multi-orgasmic men, sexual health, libido, foreplay, relationship advice, men and women, emotional regulation, stress hormones, cortisol, adrenaline, epigenetics, Parkinson's disease, protein assimilation, digestive enzymes, pre-digested protein, whey protein, casein protein, Mars Venus app, five finger ask, Venus talk, emotional processing, trauma, post traumatic stress, testosterone collapse, relationship breakdown, attraction, desire, masculine feminine polarity, Dave Asprey, 40 Years of Zen, hormones and behavior, relational biology, conscious relationships, mirror neurons and sex, luteinizing hormone, monk celibacy, meditation

    Resources:
    • Grab All Of John’s Books And Content At: https://www.marsvenus.com/
    • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
    • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
    • Danger Coffee: https://dangercoffee.com/discount/dave15
    • My Daily Supplements: SuppGrade Labs (15% Off)
    • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
    • Dave Asprey’s BEYOND Conference: https://beyondconference.com
    • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
    • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/
    • Upgrade Labs: https://upgradelabs.com

    Timestamps:
    00:00 – Trailer
    00:45 – Intro
    02:23 – Testosterone & Relationship Collapse
    02:41 – Hormones & Stress
    08:37 – Attraction & Sexual Polarity
    10:36 – Communication & Conflict
    20:21 – Emotions & Trauma
    21:27 – Mirror Neurons
    31:03 – Masculine vs. Feminine Energy
    45:05 – Lithium Orotate
    49:52 – Protein & Longevity
    54:02 – Semen Retention
    59:46 – Prolactin & Long-Term Desire
    1:09:12 – Sex & Mirror Neurons
    1:12:45 – The Five Finger Ask
    See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
  • The Human Upgrade: Biohacking for Longevity & Performance

    This Italian Fasting Hack Breaks All The Rules Of Fasting : 1464

    10/05/2026 | 19 min
    If you are constantly bloated, fatigued, and feeling heavy, your gut bacteria have taken over. The standard advice is to just stop eating and do a multi-day water fast. But if your gut is already inflamed, a strict zero-calorie fast will actually spike your cortisol, trigger adrenaline crashes, and blow open the tight junctions in your intestinal wall.

    In this video, I break down the Italian fasting hack engineered by longevity researcher Valter Longo: The Fasting Mimicking Diet (FMD).

    I explain exactly how to structure this 5-day protocol to trick your body into autophagy (cellular cleanup) while still eating 800 to 1100 calories of specific fats and complex carbs. You will learn how constant "grazing" paralyzes your Migrating Motor Complex, why hidden proteins in vegetables are secretly kicking you out of fasting mode, and the exact step-by-step protocol to re-feed your microbiome on Day 6 without causing a massive inflammatory storm.

    Thank you to our sponsors!
    -GOT MOLD? | Go to http://gotmold.com/shopand use DAVE10 to save 10% and see what’s in your air
    -The One Device | Use code DAVE for $10 off at theonedevice.com/dave
    -iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE

    Timestamps:
    00:00 – Intro
    00:40 – Gut Ecosystem
    01:00 – Constant Snacking
    02:57 – Gut-Brain Connection
    03:40 – Why Standard Fasting Can Backfire
    07:22 – The Fasting Sweet Spot
    09:21 – Introducing the FMD
    10:43 – Pre-Reset: Prep Days
    13:24 – The 5-Day FMD Protocol
    16:47 – Meal Timing & Circadian Rhythm
    17:46 – Sleep, Stress & Recovery
    18:22 – How Often to Do FMD
    19:23 – Wrapup

    Connect with Dave Asprey!

    Website: https://daveasprey.com
    TikTok: https://www.tiktok.com/@daveaspreyofficial
    Instagram: https://www.instagram.com/dave.asprey/
    Facebook: https://www.facebook.com/Daveaspreyofficial/
    X: https://x.com/daveasprey
    YouTube: https://www.youtube.com/c/daveaspreybpr

    The Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/

    Danger Coffee: https://dangercoffee.com/DAVE15
    Dave Asprey’s BEYOND Conference: https://beyondconference.com/
    Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/
    Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15
    Upgrade Labs: https://upgradelabs.com
    40 Years of Zen: https://40yearsofzen.com
    See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
  • The Human Upgrade: Biohacking for Longevity & Performance

    Pandemic Fever Is BACK, Testosterone and Brain Tumors, Rabies, and Dog Flu : 1463

    08/05/2026 | 10 min
    *Testosterone Directly Suppresses Brain Tumor Growth in Males by 38%
    Cleveland Clinic research funded by NIH shows testosterone binds androgen receptors in glioblastoma stem cells — the root of tumor recurrence — and cuts growth by 38% when levels are restored. Dave breaks down why the mainstream framing of testosterone and cancer risk has it backwards, what androgen deprivation therapy may be doing to every other cancer pathway simultaneously, and why your hormone panel is now a cancer conversation, not just a performance one.
    Sources:
    -https://www.nih.gov/news-events/news-releases/nih-funded-study-suggests-testosterone-suppresses-brain-tumor-growth-males
    -https://bioengineer.org/nih-funded-research-indicates-testosterone-may-inhibit-brain-tumor-growth-in-males/


    *CDC Halts Rabies Testing Nationwide
    A CDC staffing crisis has pushed rabies, mpox, and Epstein-Barr testing to overwhelmed state labs, creating one-to-two week diagnostic delays in a disease where post-exposure prophylaxis must begin within ten days of a bite — and where fatality is virtually 100% once symptoms appear. Dave explains exactly what to do if you or a pet is exposed, why outdoor biohackers are the most exposed population, and what pre-travel prevention looks like for anyone heading to endemic regions.
    Sources:
    -https://www.nbcnews.com/health/health-news/cdc-pauses-testing-rabies-monkeypox-epstein-barr-viruses-rcna266377
    -https://www.cidrap.umn.edu/rabies/state-public-health-labs-step-cdc-pauses-testing-various-pathogens-including-rabies-mpox


    *Mifepristone Mail Ban
    The Supreme Court issued a one-week stay blocking a 5th Circuit ruling that would have ended telehealth and mail access to mifepristone, used in over 63% of U.S. abortions. Dave sets aside the moral debate to focus on what this legal precedent means for FDA-approved compounded peptides, bioidentical hormones, and telehealth access to any treatment without full pharmaceutical backing — and why this case is one every biohacker should be tracking closely.
    Sources:
    -https://www.usnews.com/news/health-news/articles/2026-05-05/supreme-court-issues-stay-keeping-abortion-pill-mifepristone-available-by-mail-for-now
    -https://www.npr.org/2026/05/04/nx-s1-5810510/supreme-court-mifepristone-appeals-telehealth

    *Cow Flu and Dog Coronavirus
    University of Florida scientists are watching Influenza D — endemic in U.S. cattle herds — and canine coronavirus HuPn-2018, which already jumped to humans in China, as the two zoonotic threats most likely to achieve widespread human transmission. Dave covers why the conditions producing these jumps aren't going away, what the Influenza D finding means for the raw milk conversation right now, and the mucosal immunity stack that puts you in the strongest position regardless of which virus makes the leap next.
    Sources:
    -https://ufhealth.org/news/2026/scientists-say-these-two-viruses-may-become-the-next-public-health-threats
    -https://www.gavi.org/vaccineswork/six-major-health-threats-could-shape-2026-heres-what-experts-are-watching

    *Hantavirus Kills 3 on Cruise Ship
    Eight confirmed or suspected cases of Andes hantavirus aboard the MV Hondius off the Canary Islands have killed three and left two critical, with passengers from 23 countries already dispersed through global airports. Dave cuts through the pandemic panic to explain why American and South American hantavirus strains are categorically more lethal than European ones, why Andes is the only strain on earth that spreads human to human via respiratory droplets, and what early symptom recognition could mean for your survival window if exposure reaches your community.
    Sources:
    -https://www.cnn.com/2026/05/07/world/hantavirus-ship-tenerife-outbreak-intl
    -https://www.nbcnews.com/health/health-news/hantavirus-andes-virus-what-is-cruise-ship-outbreak-deadly-strain-rcna343901


    This episode is designed for biohackers, longevity seekers, and high-performance listeners who want mechanism-level clarity on hormonal optimization, infectious disease risk, immune resilience, and the legal infrastructure shaping medical autonomy. Host Dave Asprey connects emerging NIH research, Supreme Court developments, and live outbreak data into actionable frameworks for protecting your biology when institutions can't do it for you.


    New episodes every Tuesday, Thursday, Friday, and Sunday.


    Keywords: testosterone brain cancer, testosterone glioblastoma, low testosterone tumor risk, androgen deprivation therapy cancer, CDC rabies testing paused, rabies post-exposure prophylaxis, rabies exposure protocol, mifepristone telehealth ban, SCOTUS mifepristone stay, telehealth medical autonomy, compounded hormones legal risk, influenza D cattle virus, canine coronavirus HuPn-2018, zoonotic virus 2026, raw milk bird flu risk, mucosal immunity biohacking, hantavirus cruise ship, Andes hantavirus outbreak, MV Hondius hantavirus, hantavirus human to human transmission, hantavirus vs coronavirus, biohacking news 2026, Dave Asprey weekly roundup, longevity research 2026


    Thank you to our sponsors!
    - Dave Asprey's 2026 Clean Nicotine Roadmap | Enroll for free at: daveasprey.com/2026-clean-nicotine-roadmap
    - Essentia | Go to https://myessentia.com/dave and use code DAVE for $100 off The Dave Asprey Upgrade.
    - iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE


    Resources:
    • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
    • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/
    • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
    • Danger Coffee: https://dangercoffee.com/discount/dave15
    • My Daily Supplements: SuppGrade Labs (15% Off)
    • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
    • Dave Asprey’s BEYOND Conference: https://beyondconference.com
    • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
    • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/
    • Upgrade Labs: https://upgradelabs.com


    Timestamps:
    00:00 – Intro
    00:35 – 1. Testosterone & Brain Cancer
    02:30 – 2. CDC Pauses Rabies Testing
    04:09 – 3. Mifepristone & Telehealth Access
    05:42 – 4. Influenza D & Canine Coronavirus
    07:15 – 5. Hantavirus Cruise Ship Outbreak
    09:36 – Takeaways
    See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
  • The Human Upgrade: Biohacking for Longevity & Performance

    iPhone Poisoning Is REAL: Here's How To Reverse the Hidden Damage | Quantum Upgrade : 1462

    07/05/2026 | 36 min
    What if an invisible field could protect your brain from EMF damage, improve your HRV, accelerate recovery, and optimize your biology without pills, devices, or a single lifestyle change? Host Dave Asprey sits down with Philippe Samor von Holtzendorff-Fehling, founder of Leela Quantum Tech and Quantum Upgrade, to explore one of the most controversial and compelling frontiers in biohacking today: quantum energy fields delivered remotely, in real time, to your body, your pets, your home, and even your business.

    -Try Quantum Upgrade Free for 15 days, no credit card required: quantumupgrade.io/dave
    -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR

    Philippe Samor von Holtzendorff-Fehling is a coach, conscious entrepreneur, and energy healer who built a parallel path alongside a high-level international business career, working through his own blockages to fully connect with his true self. He served as Vice President at both T-Mobile International and T-Mobile US, and is now the founder and CEO of Leela Quantum Tech and Quantum Upgrade. He is also a kundalini yoga teacher, a passionate bio and bio-energy hacker, a father of two, a dog lover, and the number one ranked tennis player in the US in the Men 50+ category. His work sits at the intersection of functional medicine, quantum biology, and human performance, and the science behind his technology is harder to dismiss than most people expect.

    Dave and Philippe go deep on how chronic EMF exposure from 5G towers, Starlink satellites, electric vehicles, and everyday Wi-Fi actively disrupts your brain waves, blood cells, heart rate variability, and mitochondria function. They also break down how Quantum Upgrade works as a remote, customizable field that can harmonize these frequencies in real time, and why it may be one of the most underrated tools for sleep optimization, brain optimization, recovery, anti-aging, and longevity.

    This episode also covers the groundbreaking work Philippe is doing with autistic children, including a clinical study showing measurable reductions in autism spectrum scores, and a remarkable collaboration with Susie Miller of the Telepathy Tapes.

    This is essential listening for anyone serious about biohacking, human performance, anti-aging, longevity, brain optimization, sleep optimization, functional medicine, mitochondria health, and hacking every system in your body with smarter not harder solutions.

    You'll Learn:
    Why EMF from 5G, Starlink, and electric vehicles is more biologically dangerous than most people realize
    How a 256-channel EEG captured real-time brain changes triggered by Quantum Upgrade
    What "quantum coherence" actually means for your biology and why it matters for human performance and longevity
    How remote quantum fields affect HRV, blood clarity, ATP production, and mitochondria function
    Why autistic children showed measurable spectrum score reductions in a clinical trial using this technology
    How to customize your own quantum field for sleep optimization, recovery, energy, and brain optimization
    What Dave uses Quantum Upgrade for at his 40 Years of Zen facility in Austin

    Thank you to our sponsors!
    - Superstratum Labs | Get Dave's exact home mold detox kit and save 10% at superstratumlabs.com/products/dave
    - Suppgrade Labs | Grab your DAKE and Minerals 101 duo at shopsuppgradelabs.com and use code DAVEPOD for 15% off today
    - Timeline | Go to timeline.com/dave and you’ll get an additional 20% off your first month
    - Amp | If you're ready to make fitness fit into your life, go to amp.ai to check it out

    Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.

    New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.

    Keywords: Philippe Samor von Holtzendorff-Fehling, Quantum Upgrade, Leela Quantum Tech, quantum energy, EMF protection, electromagnetic fields, 5G health effects, Starlink radiation, biohacking, human performance, longevity, anti-aging, brain optimization, sleep optimization, mitochondria, functional medicine, HRV, heart rate variability, dark field microscopy, EEG, ATP production, quantum coherence, biofield, energy healing, autism spectrum, telepathy tapes, Susie Miller, kundalini yoga, electric vehicle EMF, Wi-Fi health effects, smarter not harder, Dave Asprey, 40 Years of Zen, wound healing, placebo controlled trials, quantum biology, coherent field, EMF harmonization, remote quantum field, energy frequency, conscious entrepreneurship

    Resources:
    • Try Quantum Upgrade Free for 15 days, no credit card required: quantumupgrade.io/dave
    • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
    • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
    • Danger Coffee: https://dangercoffee.com/discount/dave15
    • My Daily Supplements: SuppGrade Labs (15% Off)
    • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
    • Dave Asprey’s BEYOND Conference: https://beyondconference.com
    • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
    • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/
    • Upgrade Labs: https://upgradelabs.com

    Timestamps:
    00:00 – Trailer
    01:15 – What Science Can't Explain
    04:05 – What Is Quantum Upgrade?
    06:04 – The Research
    07:47 – Origin Story
    12:20 – EEG Testing & Brain Effects
    12:53 – EMFs, Electric Cars & 5G
    17:57 – Measuring Results
    21:25 – Autism Study & Telepathy Tapes
    26:16 – Frequencies & Settings
    29:09 – Starlink & Global EMF
    30:54 – Skeptics & Proof
    33:08 – Kids & Pets
    37:10 – Wrap-Up & Free Trial
    See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
  • The Human Upgrade: Biohacking for Longevity & Performance

    Eat These Foods + Spices for 8 Weeks To Get 3 Years Younger | Kara Fitzgerald : 1461

    05/05/2026 | 54 min
    Your biological age can drop by over three years in just eight weeks, and the tools to do it are already in your kitchen. This episode breaks down the cutting-edge science of methylation, polyphenols, Yamanaka mimetics, and epigenetic reprogramming that is rewriting what we know about anti-aging, longevity, and human performance.

    -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR

    Host Dave Asprey sits down with Dr. Kara Fitzgerald, ND, IFMCP, a leading voice in functional medicine and epigenetic aging research. Her award-winning clinical studies published in Aging (2021, 2023, and 2025) proved that targeted diet and lifestyle interventions can measurably reverse biological age on validated epigenetic clocks. She is the author of Younger You, an IFM faculty member and Certified Practitioner, and one of the most rigorously credentialed researchers working at the intersection of functional medicine, nutrition, and longevity science today.

    Together, they go deep on Yamanaka factors, the Nobel Prize-winning discovery that can wind back a 90-year-old cell to its 20s, and the emerging class of compounds called Yamanaka mimetics, polyphenol-based supplements that may replicate some of those same cellular rejuvenation effects without the risks. They cover why polyphenols do the heavy lifting in biological age reversal, how AI is accelerating longevity research, and why the dark matter of nutrition may matter more than macros, carnivore protocols, or ketosis for long-term health. They also get into oxalates, mitochondria, fibroids, ovarian rejuvenation, and why the original Horvath clock may be more relevant than scientists thought.

    This is essential listening for anyone serious about biohacking, longevity, supplements, functional medicine, anti-aging, brain optimization, human performance, and using smarter not harder strategies to take control of your biology.

    You'll Learn:
    How diet, supplements, and meditation reversed biological age by over three years in eight weeks in a randomized controlled trial
    What Yamanaka factors are and why scientists are calling partial cellular reprogramming the future of anti-aging
    Which polyphenols do the heaviest lifting for epigenetic rejuvenation, including EGCG, urolithin A, rosemary, marjoram, and yarrow
    Why the Horvath epigenetic clock may actually be touching on programmatic aging rather than just exposomic wear and tear
    How AI is unlocking patterns in longevity data that no human researcher could find alone
    The problem with high-oxalate superfoods and how to get polyphenol benefits without the inflammatory downside
    Why ovarian rejuvenation may be the highest-leverage Yamanaka application for women's longevity and brain health
    How compounds like AKG, sodium butyrate, and forskolin may act as Yamanaka mimetics already available today
    What the PRC2 polycomb clock reveals about programmatic aging and why it matters more than second-generation clocks
    Why perimenopause does not have to be painful, and how functional medicine addresses it at the root


    Thank you to our sponsors!
    - Screenfit | Get your at-home eye training program for 40% off using code DAVE at https://www.screenfit.com/dave.
    - Viome | Check it out at viome.com and use code 10DAVE for 10% off. It’s time to stop guessing and start knowing your body.
    - STEMREGEN | Go to stemregen.co/dave30 Use code DAVE30 for 30% OFF your next order.
    - Caldera + Lab | Go to https://calderalab.com/DAVE and use code DAVE at checkout for 20% off your first order.

    Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.

    New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.

    Keywords: Kara Fitzgerald, biological age reversal, epigenetics, DNA methylation, Yamanaka factors, polyphenols, EGCG, urolithin A, anti-aging, longevity, biohacking, functional medicine, supplements, mitochondria, epigenetic clock, cellular reprogramming, AKG, sodium butyrate, methylation, Steve Horvath, Vittoria Sebastiano, coleus, perimenopause, ovarian rejuvenation, pluripotent stem cells, PRC2, dark matter of nutrition, TRIM study, dihydroxyflavone, BDNF, Prenuvo, chemical cellular rejuvenation

    Resources:
    • Learn more about all of Dr. Fitzgerald’s work at: https://www.drkarafitzgerald.com/
    • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
    • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
    • Danger Coffee: https://dangercoffee.com/discount/dave15
    • My Daily Supplements: SuppGrade Labs (15% Off)
    • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
    • Dave Asprey’s BEYOND Conference: https://beyondconference.com
    • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
    • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/
    • Upgrade Labs: https://upgradelabs.com

    Timestamps:
    0:00 – Trailer
    1:28 – Explaining Study
    3:45 – What Is The Diet
    6:49 – Age Reversal
    8:17 – Polyphenols vs. Supplements
    9:27 – Food vs. Supplement Dosing
    12:41 – Oxalate & Polyphenol Trade-offs
    18:41 – Yamanaka Factors Explained
    28:59 – Chemical Cocktails
    32:15 – PRC2 Clocks & Programmatic Aging
    40:28 – Seasonal Eating
    43:40 – Carnivore Diet: Short vs. Long Term
    45:31 – Inuit Diet
    46:39 – Flavones & Brain-Crossing Compounds
    48:50 – Why Only Men in the Study?
    51:05 – Women, Perimenopause & the Protocol
    53:20 – Fibroids & Gaps in Women's Research
    See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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Acerca de The Human Upgrade: Biohacking for Longevity & Performance
For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization.Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more.This isn’t just self-improvement - it’s human enhancement backed by data.Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life.Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.
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