Your Brain On

• Your Brain On... Diabetes

  Behind the staggering statistics on global diabetes prevalence are millions of individuals with different stories, struggles, and solutions. In this episode, we explore how diabetes affects your brain, body, and cognition, and how it can be prevented, managed, and (in many cases) reversed. We share some powerful personal stories from the clinic, bust some persistent food myths, and learn why diabetes is as much a neurological emergency as a metabolic one. Plus, we speak to three leading experts who are changing the way we treat diabetes: BRENDA DAVIS, RD: renowned dietitian and global authority on plant-based nutrition. DR. MICHELLE MCMACKEN, MD: Executive Director of Nutrition and Lifestyle Medicine at NYC Health + Hospitals, Associate Professor at NYU, and public health leader. DR. THEODORE FRIEDMAN: Professor and Chair of Internal Medicine at Charles Drew University. In this episode, we discuss: • The difference between Type 1, Type 2, and prediabetes • How diabetes can contribute to cognitive decline • The role of lipotoxicity and intramuscular fat in insulin resistance • Why “cutting carbs” isn’t the full story (and how to focus on food quality) • How public health systems are evolving to make prevention accessible and equitable • The real science behind CGMs (and why glucose spikes shouldn’t cause a panic) • How new drugs like Ozempic can support (but not replace) lifestyle change This is... Your Brain On Diabetes. SUPPORTED BY: NEURO World. Help your brain thrive, now and into the future: https://neuro.world/  ‘Your Brain On’ is hosted by neurologists, scientists, and public health advocates Ayesha and Dean Sherzai.  ‘Your Brain On... Diabetes’ • SEASON 5 • EPISODE 10 [FINALE] Season 6, coming soon! LINKS Brenda Davis’ website: https://brendadavisrd.com/ Dr. McMacken at NYC Health: https://med.nyu.edu/faculty/michelle-mcmacken Dr. Theodore Friedman at CDU: https://www.cdrewu.edu/directory/friedman-md-phd-theodore/

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• Your Brain On... Alzheimer’s (Mythbusting Special)

  Alzheimer’s disease is constantly surrounded by myths and misinformation. Let’s set the record straight. In this episode, we bust through the most persistent Alzheimer’s myths, with facts based on decades of clinical experience and cutting-edge research. Myths include: • “Alzheimer’s is inevitable in old age” • “It’s all genetic, and there’s nothing you can do” • “There’s no cure, so diagnosis is useless” • “Supplements and vitamins can prevent or cure Alzheimer’s” • “Statins and vaccines cause Alzheimer’s” Plus many others. We also share our science-backed insights and practical tips for helping you prevent cognitive decline, starting TODAY. ‘Your Brain On... Alzheimer’s (Mythbusting Special)’ • SEASON 5 • EPISODE 9 SUPPORTED BY: NEURO World. Help your brain thrive, now and into the future: https://neuro.world/ ‘Your Brain On’ is hosted by neurologists, scientists, and public health advocates Ayesha and Dean Sherzai. CONNECT WITH THE BRAIN DOCS Website: https://thebraindocs.com/ Instagram: https://www.instagram.com/thebraindocs TikTok: https://www.tiktok.com/@thebraindocs

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• Your Brain On... Purpose (Sherzai Family Special)

  With big changes happening in the Sherzai family household, we sat down for a roundtable discussion about the concept that will shape what we’re all doing next: our purpose. In this ‘unplugged’ mid-season chat, we’re joined by our kids — Sophia and Alex! — for a wide-ranging conversation about our values and goals. How they form, how they falter, and how they evolve, in an increasingly noisy world. Together, we discuss: • The neurological and evolutionary importance of purpose • How a firm sense of purpose can help us develop better habits • The difference between ‘internal’ and ‘external’ purpose • How we can stay focused on our values in the face of modern life’s distractions • The promises and pitfalls of AI in shaping (and potentially hijacking) our sense of purpose Sophia — now heading off to Boston! — works in biomedical engineering and brain-computer interfaces. And Alex (self-proclaimed Tetris champion) is focused on the intersection of brain health and artificial intelligence. This is Your Brain On... Purpose, a Sherzai Family Special!

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• Your Brain On... Creatine

  Creatine for Alzheimer’s — let’s separate the hype from the hope. A new study has caused a stir in June 2025, but lead researcher Matthew K. Taylor told us: “ I don’t think I can recommend it to a patient that this is going to ultimately have some sort of cognitive influence.” We speak to Dr. Taylor and Dr. Russell Swerdlow in this episode, discussing: • Role of creatine in your brain, and why it matters for energy metabolism • What the 2025 study found (and why it wasn’t designed to prove effectiveness) • How scientific nuance gets lost in supplement hype • Why even promising early data must be handled with care • The vital difference between hype and hope Dr. Russell Swerdlow, MD is Director of the University of Kansas Alzheimer’s Disease Research Center. Dr. Matthew Taylor, PhD, RD is Associate Professor of Dietetics & Nutrition at the University of Kansas Medical Center. This is... Your Brain On Creatine. SUPPORTED BY: NEURO World. Help your brain thrive, now and into the future: https://neuro.world/  ‘Your Brain On’ is hosted by neurologists, scientists, and public health advocates Ayesha and Dean Sherzai.  ‘Your Brain On... Creatine’ • SEASON 5 • EPISODE 8 LINKS  Dr. Taylor at the University of Kansas: https://www.kumc.edu/mtaylor3.html Dr. Swerdlow at the University of Kansas: https://www.kumc.edu/rswerdlow.html REFERENCES 1. Smith AN, Choi IY, Lee P, Sullivan DK, Burns JM, Swerdlow RH, Kelly E, Taylor MK. Creatine monohydrate pilot in Alzheimer's: Feasibility, brain creatine, and cognition. Alzheimer's & Dementia: Translational Research & Clinical Interventions. 2025 Apr;11(2):e70101. 2. Taylor MK, Burns JM, Choi IY, et al. Protocol for a single-arm, pilot trial of creatine monohydrate supplementation in patients with Alzheimer’s disease. Pilot Feasibility Study. 2024;10(1):42.  3. Habeck C, Risacher S, Lee GJ, et al. Relationship between baseline brain metabolism measured using [18 F]FDG PET and memory and executive function in prodromal and early Alzheimer’s disease. Brain Imaging Behav. 2012;6(4):568-83.  4. Kreider RB, Kalman DS, Antonio J, et al. International Society of Sports. Nutrition position stand: safety and efficacy of creatine supplementation in exercise, sport, and medicine. J Int Soc Sports Nutr. 2017;14:18.

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• Your Brain On... Stress

  Stress isn’t just a threat to your brain. It’s also one of its best tools for growth. We often hear that stress is bad for your brain. And it can be. Chronic, unpredictable, and uncontrollable stress can damage cognition, harm memory, and accelerate aging. But we don’t talk enough about how the right kind of stress can actually improve brain function, grow your hippocampus, and help you feel happier and more purposeful. In this episode of Your Brain On..., we explore the science of stress with two brilliant guests: Dr. Sharon Bergquist, Yale- and Harvard-trained internal medicine physician and author of ‘The Stress Paradox’ Dr. Mithu Storoni, neuroscientist and author of ‘Stress-Proof’ and ‘Hyper Efficient’ Together, we explore: • The biological difference between good and bad stress • Why ‘eustress’ (good stress) can actually build your brain • Balancing stress: not too little, not too much • How to use stress as a tool to enhance resilience and protect against aging • What brain imaging reveals about stress hormones, attention, and burnout • Practical ways to reframe, recover from, and even seek out positive stress This is... Your Brain On Stress. SUPPORTED BY: NEURO World. Help your brain thrive, now and into the future: https://neuro.world/  ‘Your Brain On’ is hosted by neurologists, scientists, and public health advocates Ayesha and Dean Sherzai. ‘Your Brain On... Stress’ • SEASON 5 • EPISODE 7 LINKS Dr. Sharon Bergquist’s website: https://drsharonbergquist.com/  ‘The Stress Paradox’: https://www.harpercollins.com/products/the-stress-paradox-sharon-horesh-bergquist Dr. Mithu Storoni’s website: https://www.mithustoroni.com/ Stress-Proof: https://www.mithustoroni.com/stress-proof CONNECT WITH US Join NEURO World: https://neuro.world/  Instagram: https://www.instagram.com/thebraindocs YouTube: https://youtube.com/thebraindocs Website: TheBrainDocs.com

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