S3 E3 The Oncology Journal Club Podcast: To INFINITY and Beyond! Rethinking Treatment Paradigms and Common Sense Trial Design
Send us a textWelcome to The Oncology Journal Club Podcast Series 3Hosted by Professor Craig Underhill, Dr Kate Clarke & Professor Christopher Jackson | Proudly produced by The Oncology NetworkThe Oncology Journal Club team take a deep dive into three standout papers:Craig kicks us off with a timely perspective on the long-term toxicity of immune checkpoint inhibitors—are we ready to widen the lens? He highlights the need for more comprehensive research on survivorship issues including quality of life, financial impact and psychological outcomes.Kate brings us the exciting results from the INFINITY study on gastric and gastroesophageal cancers which shows impressive complete response rates in dMMR gastric cancers but at prohibitive costs — and poses a big question: are we ready to rethink treatment paradigms?And CJ unpacks the Common Sense Oncology principles for designing better phase 3 trials — Common Sense Oncology principles offer a patient-centred framework for designing and reporting clinical trials.Of course, we’ve also got our Quick Bites—those quirky, surprising papers that made us raise an eyebrow or two. From RNA vaccines in pancreatic cancer to updated ASCO guidelines for small cell lung cancer, it’s a rapid-fire segment you won’t want to miss.For links to the papers discussed and bios of our hosts, head to the show notes on oncologynetwork.com.au.Subscribe to The Oncology Newsletter for regular updates on the latest cancer research and join our community at oncologynetwork.com.au.The Oncology Podcast - An Australian Oncology Perspective
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S3E2 The Oncology Journal Club Podcast: Is DEI Dead? The Future of Diversity, Equity and Inclusion in Healthcare
Send us a textWelcome to The Oncology Journal Club Podcast Series 3Hosted by Professor Craig Underhill, Dr Kate Clarke & Professor Christopher Jackson | Proudly produced by The Oncology NetworkThe Oncology Journal Club hosts break from their usual format to discuss the impact of political shifts on diversity, equity and inclusion in cancer research and treatment worldwide.Recent political developments threaten progress in cancer research, particularly through attacks on the NIH, CDC and other scientific institutionsEvidence shows that diversity in healthcare leadership leads to better patient outcomes and financial performanceCensorship of scientific language related to gender and equity raises serious concerns about academic freedomDEI initiatives aren't just political—they are clinical; with evidence that they save lives, with examples from bowel cancer treatment in New ZealandRepresentation in medical fields matters for patient engagement, with data showing improved outcomes when clinicians reflect the communities they serveRegional cancer centres can match metropolitan survival rates through targeted funding and research, saving approximately 90 lives annually in one Australian communityThe hosts encourage colleagues to speak up where possible while supporting those who cannot due to political pressuresPlease share your thoughts with us via social media or email. We'd love to hear your feedback on this important discussion.Subscribe to The Oncology Newsletter for regular updates on the latest cancer research and join our community at oncologynetwork.com.au.The Oncology Podcast - An Australian Oncology Perspective
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S3E1 The Oncology Journal Club Podcast: ASCO GI Highlights 2025
Send us a textWelcome to The Oncology Journal Club Podcast Series 3! Proudly produced by The Oncology NetworkThree respected oncologists dive deep into the most significant research presented at ASCO GI 2025, bringing you practice-changing insights amidst a backdrop of political uncertainty affecting medical research.Professor Chris Karapetis joins hosts Professor Craig Underhill and Professor Christopher Jackson to unpack ground-breaking colorectal cancer studies that are reshaping treatment paradigms. The conversation explores how targeted therapies are dramatically improving survival rates, with the DEEPER study demonstrating cetuximab's superiority over bevacizumab for left-sided RAS wild-type disease, achieving an impressive 50-month median survival when combined with chemotherapy.The experts dissect the BREAKWATER trial, which shows promising benefits of combining encorafenib and cetuximab with chemotherapy for notoriously aggressive BRAF-mutant colorectal cancer. This combination achieved a 61% response rate versus 40% with standard care, with responses lasting significantly longer – representing a potential new standard of care for this difficult-to-treat subgroup.Perhaps most surprisingly, our panel discusses how an inexpensive, familiar medication – aspirin – could reduce colorectal cancer recurrence by 40% in patients with PIK3CA mutations according to the ALASCCA study. This finding highlights how molecular profiling is becoming essential across treatment stages, not just for expensive targeted therapies but also for optimising use of accessible interventions.The discussion extends to exciting developments in pancreatic cancer with a novel pan-RAS inhibitor showing meaningful activity, and advancements in immunotherapy for MSI-high colorectal cancer, confirming combination therapy's superiority. For gastrointestinal oncologists navigating an increasingly complex treatment landscape, this episode offers crucial insights to optimise patient outcomes through precise, personalised approaches.Subscribe to The Oncology Newsletter for regular updates on the latest cancer research and join our community at oncologynetwork.com.au.The Oncology Podcast - An Australian Oncology Perspective
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Nothing to fear? Facing the challenge of fear of cancer recurrence
Send us a textConfronting the Fear of Cancer RecurrenceWelcome to the latest Series of Supportive Care Matters, a podcast hosted by Medical Oncologist and International Cancer Survivorship Expert, Professor Bogda Koczwara AM.The fear of cancer returning is a silent struggle for many survivors, often overshadowing their recovery. In Episode 1 of this new Series, Bogda explores this deep-seated anxiety with experts Professor Sophie Lebel and Associate Professor Ben Smith.They unpack the realities of recurrence fears — why they persist, who is most affected and how they impact daily life. Research shows nearly every cancer survivor experiences some level of worry, but for 40%, it becomes a significant source of distress. Caregivers, too, often share in this burden.Sophie and Ben highlight the need for better interventions, especially for underrepresented groups, and share practical strategies for managing fear in clinical settings. From open conversations to structured support pathways, they highlight ways to help survivors move forward with confidence.Join us for an insightful discussion on breaking the cycle of fear and fostering a more supportive, hopeful survivorship journey.Visit www.oncologynews.com.au for show notes and more information about Supportive Care Matters.This conversation is proudly produced by the Podcast Team at The Oncology Podcast, part of the Oncology Media Group Australia.
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The Oncology Journal Club Christmas Special 2024: Celebrating a Year of Cancer Research and Treatment Innovations
Send us a textG’day G’day G’day! Or should we say Ho! Ho! Ho!Welcome to The Oncology Journal Club Podcast’s Christmas Special!Where we take our fun and educational oncology learning resource for medical professionals to new festive heights.Produced by Rachael Babin, from The Oncology Podcast. Joined by our esteemed hosts: Professor Craig Underhill, Dr. Kate Clarke, and Professor Christopher Jackson.Join us as we reflect on the year's most impactful studies and developments of 2024. You'll discover the best papers of the year, the worst papers and of course, our favourite ‘blow your own trumpet' paper. You’ll also find out which host’s most listened to track of the year was by Beyonce.----This episode is dedicated to the memory of Russell Conley. Join us as we honour Russell's extraordinary contributions, whose legacy in GI cancer research will continue to resonate for years to come.For papers, bios and other links visit the Show Notes on our website.For the latest oncology news visit www.oncologynews.com.au.We invite healthcare professionals to join The Oncology Network for free - you'll also receive our free weekly publication The Oncology Newsletter.The Oncology Podcast - An Australian Oncology Perspective
The Oncology Podcast including The Oncology Journal Club Podcast by Professor Craig Underhill, Dr Kate Clarke and Professor Christopher Jackson; and Supportive Care Matters by Dr. Bogda Koczwara.Oncology News and Expert Analysis from a unique Australian viewpoint. Proudly brought to you by The Oncology Network. The Oncology Network are producers of digital resources that support busy oncology health professionals. For more information visit our website www.oncologynetwork.com.au.We also invite Healthcare Professionals to subscribe to The Oncology Newsletter and our Oncology Portal for free and exclusive resources at: www.oncologynetwork.com.au
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