NEJM This Week

Featuring articles on asymptomatic severe aortic stenosis, kidney disease, fracture prevention in women, and residual breast cancer, the future of the U.S. physician workforce, mutant KRAS signaling, and manufactured chemicals and children’s health; a review article on the identification and treatment of alcohol use disorder; a case report of a man with loss of consciousness and a fall; and Perspectives on striking a balance, on changing Medicare payment to strengthen primary care, and on Schrödinger’s cancer.

Featuring articles on transcatheter tricuspid-valve replacement, persistent chylomicronemia, multiple myeloma, myelofibrosis, and peripherally inserted central catheter materials; a review article on heart failure with preserved ejection fraction; a case report of a woman with shortness of breath and leg edema; and Perspectives on the plight of “dual noneligible” people in the United States, Texas Executive Order GA-46, improving outcomes after fragility fractures, and on seeing the harm.

Featuring articles on advanced melanoma, atrial fibrillation, ATTR amyloidosis, and bladder cancer; a review article on cervical cancer; a Clinical Problem-Solving describing when blurry vision clouds the bigger picture; Medicine and Society’s on transitional justice and on rethinking access to HIV medicines; and Perspectives on hepatitis C therapies, on when diversity goals meet multiregional trials, and on miles to go and nowhere to sleep.

Featuring articles on cancer cachexia, MDR tuberculosis, Ebola virus disease, and severe asthma; a review article on the nonsurgical management of chronic venous insufficiency; a case report of a woman with end-stage liver disease and headache; and Perspectives on providing effective medical care to autistic people, on independent physician associations, on face-to-face learning, and on those who are well known to us.