NEJM This Week

Featuring articles on pembrolizumab perioperative therapy in breast cancer, reduced dose schedules or fractional doses of pneumococcal conjugate vaccine, and nivolumab plus ipilimumab in colorectal cancer; a review article on degenerative rotator-cuff disorders; a case report of a man with seizures and agitation; a Clinical Implications of Basic Research on boning up on boning up; and Perspectives on the Duffy null phenotype; on sickle cell trait, inequity, and the need for change, on “target trial emulation” for observational studies, and on a good day.

Featuring articles on a nationwide couple-based genetic screening; adjunctive embolization for subdural hematoma; a late-liver-stage attenuated malaria vaccine; and climate change, floods, and human health; a review article on Candida auris infections; a case report of a girl with abdominal pain; and Perspectives on Medicare’s first round of drug-price negotiation; on invisible deaths; on minding the sentinel; and on Saint Didacus, fetal death, and dual loyalty.

Featuring articles on perioperative durvalumab in bladder cancer, transcatheter valve repair for mitral regurgitation, chemoradiotherapy in gastric cancer, and lessons from England’s National Health Service; a review article on lung transplantation; a case report of a newborn with hypoxemia and a lung opacity; and Perspectives on our latest brief case studies on efforts toward equity and on forensic nurse examiners.

Featuring articles on an invasive treatment strategy in older patients with myocardial infarction, a randomized trial of very early medication abortion, therapies in stage III melanoma, and on long Covid defined; a review article on uterine fibroids; a Clinical Problem-Solving on two sides to the story; and Perspectives on the U.S. Latino HIV crisis, on reframing cerebral palsy as a lifelong disability, and on an older patient and his physician finding an immediate, resonant connection in a haunting song recalled from long ago and far away.