ATCC's Podcast: Behind the Biology

Episodios disponibles

5 de 27

Episode 27: MicroQuant™- Modernizing Quality Control Testing
In this episode, Dr. Nilay Chakraborty discusses the newly launched MicroQuant portfolio by ATCC, which consists of quantitated microbial reference materials designed to simplify quality control testing. These materials are essential for ensuring the safety and efficacy of products across various industries, including food, cosmetics, and pharmaceuticals. The portfolio includes 12 products that meet stringent regulatory requirements, focusing on ease of use and delivering consistent results in terms of colony-forming units (CFU). They highlight the importance of regulatory guidelines and how the portfolio addresses both known pathogens and adventitious agents. The conversation emphasizes the engineering innovation behind MicroQuant, which reduces preparation time from two weeks to less than a minute, offering significant cost savings and logistical benefits. The portfolio is designed to reduce genetic drift risks and ensure consistency in QC testing, with potential for future expansion based on customer input.
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24:37
Episode 26: ThawReady™- Transforming Cryopreservation for Instant Cell Functionality
Dr. Chakraborty continues his discussion on cryobiology, focusing on the innovative ThawReady™ Assay Ready Cells that his group developed. He explains that traditional cryopreservation methods cause cellular injuries that manifest when cells are thawed, leading to delayed functionality. ThawReady™ Assay Ready Cells are designed to minimize these injuries, allowing immediate use after thawing and reducing the time and effort required for cell culture. Dr. Chakraborty goes on to discuss the strategic approach ATCC took, leveraging advanced omics technologies to understand and mitigate cellular injuries. The conversation also covers the broader implications of this technology, including cost savings and enhanced efficiency. Dr Chakraborty concludes the discussion by highlighting the importance of compatibility with new characterization technologies and the need for standardization.
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21:42
Episode 25: Freezing the Future- Revolutionizing Cryopreservation at ATCC
In this episode Dr. Nilay Chakraborty, head of the Cryobiology Research and Development Department at ATCC, explains his group's focus on creating innovative technologies and products involving ATCC's organisms and cell lines. Dr. Chakraborty stresses the overall aim to improve the delivery and format of these materials to better serve customers. He then discusses the challenges of managing ATCC's extensive catalog and the importance of cryopreservation in maintaining the bioactivity of biological materials. The conversation highlights the complexities of cryopreservation, the need for different preservation recipes, and the expansion of their R&D unit to include specialized manufacturing. Dr. Chakraborty then explores the intricacies of freezing biological materials and opportunities for improving preservation processes. He also shares his background in engineering and its application to cryobiology, emphasizing the development of platform technologies and the importance of understanding biology at a deeper level for more effective preservation solutions.
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21:01
Episode 24: The Convergence of Frontiers
Join in, to hear Dr Jesse Boehm discuss the convergence of advancements that are making precision medicine more effective for a larger percentage of patients. He touches on how access to molecular profiling has become more widespread and affordable, allowing more patients to get detailed molecular information about their tumors. Dr. Boehm then mentions how new types of chemistry and drug development are making it possible to target a wider range of cancer proteins. He goes on to describe how innovations in biopsies enable real-time monitoring of tumors, providing a comprehensive molecular portrait of the tumor’s evolution. Overall, Dr. Boehm is optimistic that these and the other advancements that he discusses will significantly improve the outcome for most cancer patients within the next few decades.
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22:25
Episode 23: The Balance Between Collaboration and Competition
In this episode, Dr Jesse Boehm relates his inspiring journey into the world of translational research. Dr Boehm focuses on how his laboratory engineered solutions to complex biological problems, particularly cancer. He stresses the importance of working alongside cancer patients, sharing a very personal story and the impact it had on his perspective. Thanks to this perspective, Dr. Boehm encourages cancer scientists to consider urgency and patient impact of their research.
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21:53