The crypto native's podcast for DeFi, NFTs, and Web 3. .
Jason Choi (@mrjasonchoi), full-time crypto investor since 2018, goes deep into the technology and e...
What is DeSci? With Paul from BIO Protocol & Alex from VitaDAO
Today Jason is exploring all things DeSci. In this episode Jason is joined by BIO Protocol's CEO & Co-founder Paul Kohlhaas, as well as VitaDAO's Co-lead Alex Mukhin. In this episode we discuss: What exactly is DeSci? What is VitaDAO? How is VitaDAO set to increase human longevity How does crypto solve medical research? Medical investment incentives What is VITA-FAST? How is development enforced What are the traditional medical investment dynamics? Is DeSci a hype cycle? What is pump.science & $RIF? DeSci's roadmap And much more! Host: Jason Choi @mrjasonchoi . Not financial advice. -- Tangent is a private holdings company managing personal assets and is not a licensed investment advisor nor does it manage or accept any external capital. Nothing discussed is a solicitation for investment and is for entertainment purposes only. -- Timestamps: (00:00) Introduction (02:28) What is DeSci? (03:35) Paul’s background (07:27) VitaDAO user experience (09:34) VitaDAO’s use case (12:17) How does crypto solve medical research? (16:44) VitaDAO demographic (19:50) Investment incentives (24:09) VITA-FAST (27:05) Development enforcement (32:14) Traditional medical investment dynamics (35:07) Is DeSci a hype cycle? (40:08) What is pump.science & $RIF? (45:22) DeSci roadmap (49:35) Outro -- Twitter accounts: Jason Choi: https://twitter.com/mrjasonchoi Alex Mukhin: https://x.com/alex__mcl Paul Kohlhaas: https://x.com/paulkhls Blockcrunch: https://twitter.com/theBlockcrunch -- Blockcrunch VIP: https://blockcrunch.substack.com/ -- Disclaimer: The Blockcrunch Podcast (“Blockcrunch”) is an educational resource intended for informational purposes only. Blockcrunch produces a weekly podcast and newsletter that routinely covers projects in Web 3 and may discuss assets that the host or its guests have financial exposure to. Views held by Blockcrunch’s guests are their own. None of Blockcrunch, its registered entity or any of its affiliated personnel are licensed to provide any type of financial advice, and nothing on Blockcrunch’s podcast, newsletter, website and social media should be construed as financial advice. Blockcrunch also receives compensation from its sponsor; sponsorship messages do not constitute financial advice or endorsement. Full disclaimer: https://blockcrunch.substack.com/about
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52:05
Is This Memecoin Mania?
Today Jason and Sanat are back with another Roundtable! This time they’re discussing the memecoin hype and constant need for new narratives. In this episode we discuss: pump.fun live streaming feature Crypto cycles, market buyers, & onchain retail onboarding Cycle swings: utility vs memes Retail onboarding responsibilities The “narratives” wars Market flows: token supply The high float/high FDV debate continues... pump.fun winners, DeSci ai16z/Eliza And much more! Host: Jason Choi @mrjasonchoi . Not financial advice. -- Tangent is a private holdings company managing personal assets and is not a licensed investment advisor nor does it manage or accept any external capital. Nothing discussed is a solicitation for investment and is for entertainment purposes only. -- Timestamps: (00:00) Introduction (01:06) pump.fun live streaming feature (07:40) Crypto cycles, market buyers: onchain retail onboarding (13:58) Cycle swings: utility vs memes (18:40) Retail onboarding responsibilities (22:54) “narratives” (25:08) Market flows: token supply (33:07) The high float/high FDV debate continues... (39:59) pump.fun winners, DeSci (46:20) ai16z/Eliza (48:29) Degeneracy leading to good (49:05) Outro -- Twitter accounts: Jason Choi’s Twitter: https://twitter.com/mrjasonchoi Sanat Kapur’s Twitter: https://x.com/kapursanat Blockcrunch Twitter: https://twitter.com/theBlockcrunch -- Blockcrunch VIP: https://blockcrunch.substack.com/ -- Disclaimer: The Blockcrunch Podcast (“Blockcrunch”) is an educational resource intended for informational purposes only. Blockcrunch produces a weekly podcast and newsletter that routinely covers projects in Web 3 and may discuss assets that the host or its guests have financial exposure to. Views held by Blockcrunch’s guests are their own. None of Blockcrunch, its registered entity or any of its affiliated personnel are licensed to provide any type of financial advice, and nothing on Blockcrunch’s podcast, newsletter, website and social media should be construed as financial advice. Blockcrunch also receives compensation from its sponsor; sponsorship messages do not constitute financial advice or endorsement. Full disclaimer: https://blockcrunch.substack.com/about
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49:45
Building A Billion Dollar App: A Cheat Sheet for Crypto Founders
Today Jason is joined by Imran Khan, Core Contributor at Alliance, the leading crypto accelerator. In this episode we discuss: - Alliance’s early days - What to focus on with your App - Speculation vs skeuomorphic - Tips for Founders - Focusing on small problems first - Where to build: market research - Measuring success - Is chain focus important - Chain ideologies as pain point - Sustainable token offerings - Founder likability importance And much more! Host: Jason Choi @mrjasonchoi . Not financial advice. -- Tangent is a private holdings company managing personal assets and is not a licensed investment advisor nor does it manage or accept any external capital. Nothing discussed is a solicitation for investment and is for entertainment purposes only. -- Timestamps: (00:00) Introduction (04:00) Alliance’s early days (07:11) App focus (13:33) Speculation vs skeuomorphic (15:20) Tips for Founder (19:23) Focusing on small problems first (23:52) Where to build: market research (26:23) Measuring success (33:28) Is chain focus important (39:37) Chain ideologies as pain point (40:48) Sustainable token offerings (48:50) Founder likability importance (50:46) Outro -- Imran’s Breakpoint 2024 talk: https://www.youtube.com/watch?v=o5J7tX492uE -- Twitter accounts: Jason Choi’s Twitter: https://twitter.com/mrjasonchoi Imran Khan's Twitter: https://x.com/lmrankhan Blockcrunch Twitter: https://twitter.com/theBlockcrunch -- Blockcrunch VIP: https://blockcrunch.substack.com/ -- Disclaimer: The Blockcrunch Podcast (“Blockcrunch”) is an educational resource intended for informational purposes only. Blockcrunch produces a weekly podcast and newsletter that routinely covers projects in Web 3 and may discuss assets that the host or its guests have financial exposure to. Views held by Blockcrunch’s guests are their own. None of Blockcrunch, its registered entity or any of its affiliated personnel are licensed to provide any type of financial advice, and nothing on Blockcrunch’s podcast, newsletter, website and social media should be construed as financial advice. Blockcrunch also receives compensation from its sponsor; sponsorship messages do not constitute financial advice or endorsement. Full disclaimer: https://blockcrunch.substack.com/about
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51:39
AI Memecoin $GOAT hits $800M+ in 2 weeks - Roundtable with Taiki Maeda
Today Jason is joined by Taiki Maeda, Founder of HFA Research to discuss AI crypto agents, with a deep dive on Terminal of Truths and $GOAT. In this episode we discuss: - Terminal of Truths, Infinite Backrooms, $GOAT - Finding $GOAT - Terminal of Truths wallet/$GOAT ownership - Are AI memecoins the Loot of this cycle? - Why $GOAT is different - Proof-of-AI - LUNA AI agent, GNON, + more - Milady/GNON analogy + liquid investing - VC FOMO & AI agent utility vs narrative - Cycle analogies - Taiki’s Alex Good interview: Rise of $GOAT And much more! Host: Jason Choi @mrjasonchoi . Not financial advice. -- Tangent is a private holdings company managing personal assets and is not a licensed investment advisor nor does it manage or accept any external capital. Nothing discussed is a solicitation for investment and is for entertainment purposes only. -- Timestamps: (00:00) Introduction (04:48) Terminal of Truth, Infinite Backrooms, $GOAT (08:22) Finding $GOAT (10:06) Terminal of Truth wallet/$GOAT ownership (14:58) Are AI memecoins the Loot of this cycle? (19:39) Why $GOAT is different (23:55) Proof-of-AI (28:51) LUNA AI agent, GNON, + more (32:43) Milady/GNON analogy + liquid investing (40:26) VC FOMO & AI agent utility vs narrative (43:53) Cycle analogies (46:26) Taiki’s Alex Good interview: Rise of $GOAT (48:49) Outro -- Twitter accounts: Jason Choi’s Twitter: https://twitter.com/mrjasonchoi Sanat Kapur's Twitter: https://x.com/kapursanat Taiki Maeda's Twitter: https://x.com/TaikiMaeda2 Blockcrunch Twitter: https://twitter.com/theBlockcrunch -- Blockcrunch VIP: https://blockcrunch.substack.com/ -- Disclaimer: The Blockcrunch Podcast (“Blockcrunch”) is an educational resource intended for informational purposes only. Blockcrunch produces a weekly podcast and newsletter that routinely covers projects in Web 3 and may discuss assets that the host or its guests have financial exposure to. Views held by Blockcrunch’s guests are their own. None of Blockcrunch, its registered entity or any of its affiliated personnel are licensed to provide any type of financial advice, and nothing on Blockcrunch’s podcast, newsletter, website and social media should be construed as financial advice. Blockcrunch also receives compensation from its sponsor; sponsorship messages do not constitute financial advice or endorsement. Full disclaimer: https://blockcrunch.substack.com/about
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50:05
Why 2025 Is the Year of Memecoins - Murad Mahmudov
Today Jason is joined by Memecoin analyst Murad Mahmudov to discuss all things memecoins, including: Sound money vs meme coins Horseshoe theory: ideology exports Product vs price attention Memecoin nihilism Billion dollar market cap meme coins: blue chips Memcoin founder profile Celebrity coins/memecoins Murad’s memecoin selection And much more! Host: Jason Choi @mrjasonchoi . Not financial advice. -- Tangent is a private holdings company managing personal assets and is not a licensed investment advisor nor does it manage or accept any external capital. Nothing discussed is a solicitation for investment and is for entertainment purposes only. -- Timestamps: (00:00) Introduction (08:45) Sound money vs meme coins (19:00) Horseshoe theory: ideology exports (25:10) Product vs price attention (33:48) Memecoin nihilism (46:30) Billion dollar market cap meme coins: blue chips (52:03) Memcoin founder profile (53:58) Celebrity coins/memecoins (56:30) Murad’s memecoin selection (57:51) Outro -- Partner message: Aptos is the next-generation Layer 1 blockchain designed to enhance scalability, security, and reliability for decentralized applications. With industry-leading performance, internet-grade UX, 100X lower gas fees than comparable chains, and a thriving ecosystem - Aptos is the platform of choice for both builders and users. Find out more at https://aptosfoundation.org/ -- Twitter accounts: Jason Choi’s Twitter: https://twitter.com/mrjasonchoi Murad Mahmudov's Twitter: https://x.com/MustStopMurad Blockcrunch Twitter: https://twitter.com/theBlockcrunch -- Blockcrunch VIP: https://blockcrunch.substack.com/ -- Disclaimer: The Blockcrunch Podcast (“Blockcrunch”) is an educational resource intended for informational purposes only. Blockcrunch produces a weekly podcast and newsletter that routinely covers projects in Web 3 and may discuss assets that the host or its guests have financial exposure to. Views held by Blockcrunch’s guests are their own. None of Blockcrunch, its registered entity or any of its affiliated personnel are licensed to provide any type of financial advice, and nothing on Blockcrunch’s podcast, newsletter, website and social media should be construed as financial advice. Blockcrunch also receives compensation from its sponsor; sponsorship messages do not constitute financial advice or endorsement. Full disclaimer: https://blockcrunch.substack.com/about
The crypto native's podcast for DeFi, NFTs, and Web 3. .
Jason Choi (@mrjasonchoi), full-time crypto investor since 2018, goes deep into the technology and economics behind crypto projects to dissect trends and themes in a global context.
Nothing on this show is financial advice. Blockcrunch and its personnel may hold positions in assets discussed on the show.
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