Sean Carroll's Mindscape: Science, Society, Philosophy, Culture, Arts, and Ideas

• 303 | James P. Allison on Fighting Cancer with the Immune System

  A typical human lifespan is approximately three billion heartbeats in duration. Lasting that long requires not only intrinsic stability, but an impressive capacity for self-repair. Nevertheless, things do occasionally break down, and cancer is one of the most dramatic examples of such breakdown. Given that the body is generally so good at protecting itself, can we harness our internal security patrol - the immune system - to fight cancer? This is the hope of Nobel Laureate James Allison, who works on studying the structure and behavior of immune cells, and ways to coax them into fighting cancer. This approach offers hope of a way to combat cancer effectively, lastingly, and in a relatively gentle way.Support Mindscape on Patreon.Blog post with transcript: https://www.preposterousuniverse.com/podcast/2025/01/27/303-james-p-allison-on-fighting-cancer-with-the-immune-system/James P. Allison received his Ph.D. in biology from the University of Texas at Austin. He is currently Regental Professor and Chair of the Department of Immunology, the Olga Keith Wiess Distinguished University Chair for Cancer Research, Director of the Parker Institute for Cancer Research, and Director of the James P. Allison Institute at MD Anderson Cancer Center. He is the subject of the documentary film Jim Allison: Breakthrough. Among his numerous awards are the Breakthrough Prize in Life Sciences and the Nobel Prize in Physiology or Medicine.Web pageNobel Prize citationGoogle Scholar publicationsWikipediaSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

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• 302 | Chris Kempes on the Biophysics of Evolution

  Randomness plays an important role in the evolution of life (as my evil twin will tell you). But random doesn't mean arbitrary. Biological organisms are physical objects, after all, and subject to the same laws of physics as non-biological matter is. Those laws place constraints on how organisms can fulfill their basic functions of metabolism, reproduction, motility, and so on. Easy to say, but how can we turn this into quantitative understanding of actual organisms? Today I talk with physical biologist Chris Kempes about how physics can help us understand the size of organisms, their metabolisms, and features of major transitions in evolution.Support Mindscape on Patreon.Blog post with transcript: https://www.preposterousuniverse.com/podcast/2025/01/20/302-chris-kempes-on-the-biophysics-of-evolution/Chris Kempes received his Ph.D. in physical biology from the Massachusetts Institute of Technology. He is currently Professor and a member of the Science Steering Committee at the Santa Fe Institute. His research involves the origin of life and the constraints placed by physics on biological function and evolution.Web siteSanta Fe Institute web pageGoogle Scholar publicationsOrigins of Life online courseSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

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• 301 | Tina Eliassi-Rad on Al, Networks, and Epistemic Instability

  Big data is ruling, or at least deeply infiltrating, all of modern existence. Unprecedented capacity for collecting and analyzing large amounts of data have given us a new generation of artificial intelligence models, but also everything from medical procedures to recommendation systems that guide our purchases and romantic lives. I talk with computer scientist Tina Elassi-Rad about how we can sift through all this data, make sure it is deployed in ways that align with our values, and how to deal with the political and social dangers associated with systems that are not always guided by the truth.Support Mindscape on Patreon.Blog post with transcript: https://www.preposterousuniverse.com/podcast/2025/01/13/301-tina-eliassi-rad-on-al-networks-and-epistemic-instability/Tina Eliassi-Rad received her Ph.D. in computer science from the University of Wisconsin-Madison. She is currently Joseph E. Aoun Chair of Computer Sciences and Core Faculty of the Network Science Institute at Northeastern University, External Faculty at the Santa Fe Institute, and External Faculty at the Vermont Complex Systems Center. She is a fellow of the Network Science Society, recipient of the Lagrange Prize, and was named one of the 100 Brilliant Women in AI Ethics.Web siteNortheastern web pageGoogle Scholar publicationsWikipediaSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

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• 300 | Solo: Does Time Exist?

  A new year, and a new centennial -- 300 (regularly-numbered) episodes of Mindscape! Our tradition is to have a solo episode, and what better topic than the nature of time? Physicists and philosophers have so frequently suggested that time is some kind of illusion that it's become almost passé to believe that it might be fundamental. This is an issue where, despite the form of the question, physics has important things to say that most philosophers haven't yet caught up to. I will talk about ideas from quantum mechanics and quantum gravity that bear on the question of whether time is emergent or fundamental, and the implications of each possibility.Support Mindscape on Patreon.Blog post with transcript: https://www.preposterousuniverse.com/podcast/2025/01/06/300-solo-does-time-exist/Some of the papers discussed herein:Carroll (2008), "What If Time Really Exists?"Dyson, Kleban, and Susskind (2002), "Disturbing Implications of a Cosmological Constant."Albrecht and Sorbo (2004), "Can the Universe Afford Inflation?"Boddy, Carroll, and Pollack (2014), "De Sitter Space Without Dynamical Quantum Fluctuations."Lloyd (2016), "Decoherent Histories Approach to the Cosmological Measure Problem."Page and Wootters (1983), "Evolution Without Evolution: Dynamics Described by Stationary Observables."Albrecht (1994), "The Theory of Everything vs the Theory of Anything."Albrecht and Iglesias (2007), "The Clock Ambiguity and the Emergence of Physical Laws."See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

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• Holiday Message | Hits and Misses

  It's the end of the year, and time for our annual holiday break here at Mindscape. But as usual, we wrap up with a Holiday Message. This year, inspired by Joni Mitchell's "Hits" and "Misses" albums, I go through my scientific papers and talk about some of my favorites -- some of which were hits, in terms of making an impact on subsequent research, and some of which were misses by that standard. But I love them all! It's an excuse to talk about process -- how papers come to be, from the initial informal idea to sitting down and doing the work.Support Mindscape on Patreon.Blog post with transcript: https://www.preposterousuniverse.com/podcast/2024/12/23/holiday-message-hits-and-misses/Here are links to the papers I discuss in the episode.S.M. Carroll, G.B. Field and R. Jackiw, 1990, "Limits on A Lorentz and Parity-Violating Modification of Electrodynamics,'' Phys. Rev. D 41, 1231. [pdf file; inSPIRE]S.M. Carroll, E. Farhi and A.H. Guth, 1992, "An Obstacle to Building a Time Machine,'' Phys. Rev. Lett. 68, 263; Erratum: 68, 3368. [pdf file; inSPIRE]S.M. Carroll, E. Farhi, A.H. Guth and K.D. Olum, 1994, "Energy-Momentum Restrictions on the Creation of Gott Time Machines,'' Phys. Rev. D 50, 6190; gr-qc/9404065. [arXiv; pdf; inSPIRE]S.M. Carroll, 1998, "Quintessence and the Rest of the World,'' Phys. Rev. Lett. 81, 3067; astro-ph/9806099. [arXiv; pdf; inSPIRE]S.M. Carroll, V. Duvvuri, M. Trodden, and M.S. Turner, 2003, "Is Cosmic Speed-Up Due to New Gravitational Physics?'' astro-ph/0306438. [arXiv; pdf; inSPIRE]S.M. Carroll and J. Chen, 2004, "Spontaneous Inflation and the Origin of the Arrow of Time'', hep-th/0410270. [arXiv, inSPIRE]L. Ackerman, M.R. Buckley, S.M. Carroll, and M. Kamionkowski, 2008, "Dark Matter and Dark Radiation," arxiv:0807.5126. [arXiv; pdf; inSPIRE]S.M. Carroll, M.C. Johnson, and L. Randall, 2009, "Dynamical Compactification," arxiv:0904.3115. [arXiv; pdf; inSPIRE]C. Cao, S.M. Carroll, and S. Michalakis, 2016, "Space from Hilbert Space: Recovering Geometry from Bulk Entanglement," arxiv:1606.08444. [arXiv, inSPIRE]C. Cao and S.M. Carroll, 2018, "Bulk Entanglement Gravity without a Boundary: Towards Finding Einstein's Equation in Hilbert Space," arxiv:1712.02803. [arXiv, inSPIRE]N. Bao, S.M. Carroll, A. Chatwin-Davies, J. Pollack, and G. Remmen, 2017, “Branches of the Black Hole Wave Function Need Not Contain Firewalls," arxiv:1712.04955. [arXiv, inSPIRE]See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

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