Beauty Bytes with Dr. Kay: Secrets of a Plastic Surgeon™

In this episode of Beauty Bytes with Dr. Kay: Secrets of a Plastic Surgeon, I am joined by Dr. Koji Tanabe, a leading stem cell scientist, founder and CEO of iPeace, and one of the researchers behind the landmark development of human induced pluripotent stem cells, or iPSCs. Dr. Tanabe breaks down the science of Yamanaka factors and explains how mature cells can be reprogrammed into a younger, pluripotent state with the ability to develop into many different cell types. We explore how iPSC technology differs from traditional stem cells, PRP, exosomes, and other regenerative treatments, as well as why creating and quality-checking these cells outside the body may offer important advantages over attempting cellular reprogramming directly inside the body. Dr. Tanabe also shares how iPSC-derived cells are being explored in regenerative applications involving heart failure, Parkinson’s disease, spinal cord injury, and other areas of medicine. We dive into the future of personalized cell banking, why he believes it may be beneficial to preserve cells while you are healthy, and how iPSC-derived factors, or iPSF, are being explored for skin rejuvenation, hair restoration, and systemic longevity treatments. The iPSF treatments discussed in this episode are currently available only in Japan and are not available in the United States at this time due to differences in regulatory standards. From cellular aging and DNA mutations to epigenetic clocks, regenerative medicine, and the difference between lifespan and healthspan, this conversation offers a fascinating look at how cellular reprogramming could change the way we approach aging, disease, and the future of personalized medicine.
Clarification: During the discussion of iPSC-derived therapies for heart failure, the conversation referenced the possibility of creating patient-specific, autologous iPSC-derived cells. The currently approved application discussed in this episode is allogeneic, not autologous. Dr. Tanabe was referring to the potential for iPSC technology to be developed for personalized autologous applications.
Guest Information: Dr. Koji Tanabe is a stem cell scientist and the founder and CEO of iPeace. He spent eight years conducting research at Kyoto University in Nobel laureate Dr. Shinya Yamanaka’s laboratory and was the second author on the landmark 2007 paper describing the generation of human induced pluripotent stem cells. His work focuses on cellular reprogramming, regenerative medicine, personalized iPSC manufacturing, and the potential use of iPSC technology in longevity and future cell-based therapies. Check them out at: https://ipeace.com/en/ or @mypeace_ips.

In this Five-Minute Friday episode, Dr. Kay discusses Khloé Kardashian's recent admission about her cosmetic procedures, including a nose job and past facial fillers. This candid revelation offers a much-needed breath of fresh air in an industry often fueled by denial and curated perfection.
Explore how the Kardashian aesthetic has influenced beauty standards for over a decade, and the consequences of denying cosmetic enhancements. Dr. Kay emphasizes that this transparency is crucial for fostering healthier conversations around beauty, allowing individuals to differentiate between naturally achievable looks and medically enhanced ones. Learn why honesty from public figures can empower young people, reduce societal pressure, and pave the way for a more authentic and liberating approach to beauty.

Are you wondering why ADHD can feel so different for women, especially during perimenopause and other major hormonal transitions? In this episode of Beauty Bytes with Dr. Kay: Secrets of a Plastic Surgeon, I am joined by Dr. Jolene Brighten, a women’s health expert, author, and hormone specialist, to break down the complex relationship between ADHD, estrogen, dopamine, brain energy, and inflammation. Dr. Brighten explains why ADHD is not simply an inability to focus, but a disorder of attention regulation and executive function, and why symptoms can become more noticeable as hormones begin to fluctuate. We dive into the role of estrogen in dopamine, serotonin, acetylcholine, and norepinephrine signaling, as well as the emerging connection between ADHD and mitochondrial dysfunction. Dr. Brighten also discusses why perimenopause can intensify brain fog, forgetfulness, emotional reactivity, sleep disruption, and difficulty concentrating, and how neuroinflammation and declining brain energy may contribute. We also explore practical strategies for supporting the ADHD brain, including exercise, protein intake, blood sugar regulation, sleep optimization, magnesium, creatine, saffron, and other nutrients that may support cognitive function. From GLP-1 medications and thyroid health to stress, sleep, and lifestyle habits, this conversation looks at ADHD through a whole-body lens and gives women a clearer understanding of why their brain may feel different at different stages of life.
Guest Information: Dr. Jolene Brighten is a women’s health expert, author, and host of The Dr. Brighten Show. Her upcoming book, ADHD in Women, explores how female hormones influence ADHD symptoms across the lifespan. You can find her online at @DrJoleneBrighten and learn more about her work at drbrighten.com.

Are you noticing more hair in your shower drain or hairbrush this summer and wondering if it is time to panic? In honor of National Hair Loss Awareness Month, this Five Minute Friday episode of Beauty Bytes breaks down everything you need to know about your hair's natural shedding cycle.  
I explain exactly how to tell the difference between normal seasonal shedding, damage-induced hair breakage from chlorine and tight ponytails, and true progressive hair loss. We discuss why getting a comprehensive blood panel is the absolute first step you must take, including the specific hormone and ferritin levels your body requires to actually grow hair. Finally, I share my top regenerative and medical treatments for rescuing your follicles—from PRP microneedling and KeraFactor serums to oral minoxidil and dual-wavelength red light therapy.

Are you looking to optimize your skin health from the inside out? In this episode of Beauty Bytes, I am joined by Dr. Mark Tager, a physician, integrative aesthetics educator, and co-founder of the Vagal Nerve Society. Dr. Tager has authored 12 books, including Feed Your Skin Right and Integrative Aesthetics, and brings decades of expertise in personalized nutrition and regenerative medicine. We explore the true meaning of integrative aesthetics, noting that 5 to 10% of your blood flow goes to your skin, making internal nutrition the ultimate foundation for beauty.  We dive deep into the gut-skin connection, exploring how the standard American diet glycates your collagen and why maintaining a healthy microbiome with dietary fiber is essential for producing neurotransmitters. Dr. Tager also breaks down the incredible science of the vagus nerve, explaining its role in the body's inflammatory reflex and how tools like 4-7-8 breathing and the Truvaga transcervical device can calm a "wired and tired" nervous system. Finally, we discuss the "wild west" of peptides, the importance of genetic testing for personalized supplementation, and the psychological hardiness required for a long, passionate life.  
Guest Information:
Dr. Mark Tager is the CEO of ChangeWell and an expert in integrative aesthetics. You can find his books on Amazon or connect with him on LinkedIn and Instagram at @DRMTager.