Beauty Bytes with Dr. Kay: Secrets of a Plastic Surgeon™

Wrinkles, Aging, and Youthfulness - In the quest for youthful, radiant skin, a range of cutting-edge treatments and therapies has emerged to combat the signs of aging. From lymphatic massage, which aids in detoxification and reducing inflammation, to LED therapy that stimulates collagen production and reduces fine lines, and finally, PRP treatments with microneedling to enhance skin texture and elasticity — these innovative approaches offer promising solutions for those seeking to turn back the clock on aging skin. Join us as we delve into the science behind these treatments and discover how they can help you achieve a more youthful and vibrant appearance.

Are you fascinated by the molecular science of aging and senescence? In this episode of Beauty Bytes, I am joined by Dr. Frederick Beddingfield III, the CEO of Rubedo Life Sciences, a physician-scientist, and a former senior leader at Allergan. We focus on the cutting edge of longevity and how Rubedo is developing adaptive senotherapeutics to reverse cellular aging and extend healthspan.  Dr. Beddingfield explains the science behind their lead drug, RLS 1496, which targets the enzyme glutathione peroxidase 4 (GPX4) to regulate ferroptosis, an iron-dependent cell death pathway. We discuss how this drug not only eliminates toxic senescent cells but also acts as a "redox reset" for aged cells, reducing their biological age by improving mitochondrial function and autophagy. We also explore their groundbreaking human clinical trials, which demonstrated a 50% reduction in precancerous actinic keratoses in just four weeks without causing skin irritation. Plus, Dr. Beddingfield shares his personal biohacking stack, including low-dose rapamycin, fisetin, and quercetin.  
Guest Information:
Dr. Frederick Beddingfield III is the CEO of Rubedo Life Sciences. You can learn more about their clinical trials at rubedolifesciences.com or follow him on Instagram and LinkedIn at @FrederickBeddingfield.

Earplugs, blindfolds, or milk before bed time-if these can’t help you get a good night’s rest, you might turn to for help. But is this really the best way to solve your sleeping issues? That said, you might want to understand the mechanism behind melatonin before jumping into any impulsive decisions. Tune into this week’s Five Minutes Friday to discover the secrets behind melatonin on the market!

In this episode of Beauty Bytes with Dr. Kay: Secrets of a Plastic Surgeon, I am joined by Dr. Koji Tanabe, a leading stem cell scientist, founder and CEO of iPeace, and one of the researchers behind the landmark development of human induced pluripotent stem cells, or iPSCs. Dr. Tanabe breaks down the science of Yamanaka factors and explains how mature cells can be reprogrammed into a younger, pluripotent state with the ability to develop into many different cell types. We explore how iPSC technology differs from traditional stem cells, PRP, exosomes, and other regenerative treatments, as well as why creating and quality-checking these cells outside the body may offer important advantages over attempting cellular reprogramming directly inside the body. Dr. Tanabe also shares how iPSC-derived cells are being explored in regenerative applications involving heart failure, Parkinson’s disease, spinal cord injury, and other areas of medicine. We dive into the future of personalized cell banking, why he believes it may be beneficial to preserve cells while you are healthy, and how iPSC-derived factors, or iPSF, are being explored for skin rejuvenation, hair restoration, and systemic longevity treatments. The iPSF treatments discussed in this episode are currently available only in Japan and are not available in the United States at this time due to differences in regulatory standards. From cellular aging and DNA mutations to epigenetic clocks, regenerative medicine, and the difference between lifespan and healthspan, this conversation offers a fascinating look at how cellular reprogramming could change the way we approach aging, disease, and the future of personalized medicine.
Clarification: During the discussion of iPSC-derived therapies for heart failure, the conversation referenced the possibility of creating patient-specific, autologous iPSC-derived cells. The currently approved application discussed in this episode is allogeneic, not autologous. Dr. Tanabe was referring to the potential for iPSC technology to be developed for personalized autologous applications.
Guest Information: Dr. Koji Tanabe is a stem cell scientist and the founder and CEO of iPeace. He spent eight years conducting research at Kyoto University in Nobel laureate Dr. Shinya Yamanaka’s laboratory and was the second author on the landmark 2007 paper describing the generation of human induced pluripotent stem cells. His work focuses on cellular reprogramming, regenerative medicine, personalized iPSC manufacturing, and the potential use of iPSC technology in longevity and future cell-based therapies. Check them out at: https://ipeace.com/en/ or @mypeace_ips.

In this Five-Minute Friday episode, Dr. Kay discusses Khloé Kardashian's recent admission about her cosmetic procedures, including a nose job and past facial fillers. This candid revelation offers a much-needed breath of fresh air in an industry often fueled by denial and curated perfection.
Explore how the Kardashian aesthetic has influenced beauty standards for over a decade, and the consequences of denying cosmetic enhancements. Dr. Kay emphasizes that this transparency is crucial for fostering healthier conversations around beauty, allowing individuals to differentiate between naturally achievable looks and medically enhanced ones. Learn why honesty from public figures can empower young people, reduce societal pressure, and pave the way for a more authentic and liberating approach to beauty.