EASL Podcasts

Steatotic liver disease (SLD) research relies heavily on preclinical models, yet no single model can fully capture the complexity of human disease. In this episode, we explore the new EASL position paper on preclinical SLD models. From MASLD and MetALD to organoids and precision-cut liver slices, we discuss the strengths, limitations, and translational relevance of today's most widely used models. How do we choose the right model, and are we any closer to finding the perfect one?
Based on EASL position paper on preclinical models of steatotic liver disease
Host: Rui Castro (University of Lisbon) 
Speakers: Mathias Heikenwälder (University of Tübingen) and Suchira Gallage (University of Tübingen)
This episode is also available on EASL Campus: https://easlcampus.eu/tltm/episode-11
COI: Rui Castro has no potential conflicts of interest to disclose. Suchira Gallage and Mathias Heikenwälder have disclosed the following potential conflicts of interest: Research collaboration with OrsoBio.

Haemochromatosis remains one of the most common inherited metabolic disorders, yet it is frequently underdiagnosed and inconsistently managed in clinical practice. With widespread use of iron studies and genetic testing, clinicians are increasingly faced with questions around interpretation, penetrance, and clinical significance. In this podcast, we explore current challenges in diagnosis and management, focusing on who should be tested, how to interpret results, and which patients benefit from intervention in modern hepatology practice. 
Host: Thomas Marjot (King's College, London)
Speakers: John Ryan (Beaumont Hospital, Dublin) and Heinz Zoller (Medical University of Innsbruck)
This episode is also available on EASL Campus: https://easlcampus.eu/tltm/episode-10

In this episode, we discuss the first pig-to-human liver xenotransplantation and the breakthroughs behind the revival of xenotransplantation, examining its potential and remaining challenges. We also explore the accelerating field of machine perfusion, clarifying different approaches and reviewing the evidence supporting their role in organ assessment, optimisation, and DCD utilisation.
Host: Sarwa Darwish Murad (Erasmus University Rotterdam)
Speakers: Jeroen de Jonge (Erasmus University Rotterdam) and Matthew Armstrong (University Hospital Birmingham)
This episode is also available on EASL Campus: https://easlcampus.eu/tltm/episode-09

Spontaneous bacterial peritonitis (SBP) remains a major complication of cirrhosis - but rising antimicrobial resistance and emerging data are challenging long-standing practices.
In this episode, we review current evidence on primary and secondary prophylaxis, resistance patterns, albumin use, and treatment strategies. How should clinicians balance prevention with antimicrobial stewardship? And where might practice need to evolve in 2026?
Host: Thomas Marjot (King's College London)
Speakers:  Bogdan Procopet (Institute of Gastroenterology and Hepatology, Cluj-Napoca) and Alastair O'Brien (Royal Free Hospital, London) 
This episode is also available on EASL Campus: https://easlcampus.eu/tltm/episode-08

In this EASL DeepDive webinar, the expert panel presents and explains the key studies behind the latest recommendations included in the EASL Clinical Practice Guidelines on the management of extrahepatic cholangiocarcinoma.
Learning Objectives
To identify patients at risk for eCCA, and review the current tools and strategies for its surveillance, diagnosis, staging, and classification
To define the optimal candidates for resection and liver transplantation, and discuss challenges in the surgical management of eCCA
To discuss the role of systemic therapy in the management of eCCA across all disease stages (including neoadjuvant, adjuvant, and palliative settings)
Faculty
Luca Maroni - Moderator
Julie Heimbach - Speaker
Anna Saborowski - Speaker
Lars Aabakken - Speaker