Psychopharmacology and Psychiatry Updates

In this episode, we explore whether high-dose olanzapine — beyond the FDA-approved 20 mg ceiling — can be a viable strategy for patients with treatment-resistant schizophrenia when clozapine isn't yet an option. Can pushing the dose bridge the gap between partial response and full remission?
Faculty: Oliver Freudenreich, M.D.
Host: Richard Seeber, M.D.
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Earn 0.75 CME: Quick Take Vol. 83
Treatment-Resistant Schizophrenia: Should You Consider High-Dose Olanzapine Instead of Clozapine?

In this episode, we explore what the CANMAT guidelines say about complementary and alternative medicine (CAM) for depression — from St. John's wort to saffron — and how to have evidence-based, collaborative conversations with patients who prefer a more natural approach to treatment.
Faculty: Sagar V. Parikh, M.D., F.R.C.P.C.
Host: Richard Seeber, M.D.
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Earn 1.25 CME: Rethinking Depression Treatment: An Update of CANMAT's Guidelines
Complementary and Alternative Medicine for Depression: CANMAT Recommendations

In this episode, we explore the growing threat of xylazine — a veterinary sedative increasingly found in illicit drug supplies — and what clinicians need to know when naloxone simply isn't enough. Dr. David Gorelick breaks down the current evidence on diagnosis, treatment, and the critical gaps that remain.
Faculty: David A. Gorelick, M.D., Ph.D., D.L.F.A.P.A., F.A.S.A.M.
Host: Richard Seeber, M.D.
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Earn 0.5 CME: Quick Take Vol. 82
Xylazine ("Tranq Dope") Overdose: What Clinicians Should Know

In this episode, we explore how to select the right initial treatment for depression using the updated CANMAT guidelines. How do severity, patient preference, and treatment availability shape your first clinical move? Dr. Sagar Parikh breaks down the evidence on psychotherapy, antidepressants, and when to combine both.
Faculty: Sagar V. Parikh, M.D.
Host: Richard Seeber, M.D.
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Earn 1.25 CME: Rethinking Depression Treatment: An Update of CANMAT's Guidelines
Selecting the Initial Depression Treatment

In this episode, we explore the hidden dangers of leaving antipsychotics running long after a hospital delirium episode has resolved. Could a medication prescribed to keep your patient safe in the short term actually be harming them months later — and what does the latest evidence say about stopping it?
Faculty: Scott Beach, M.D.
Host: Richard Seeber, M.D.
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Earn 0.5 CME: Quick Take Vol. 82
Deprescribing Antipsychotics Post-Delirium: Why It Matters