The Proof with Simon Hill

Everyone wants to talk about longevity. Almost no one wants to talk about gerontology, the field that has been studying how to age well for a century. Dr Deborah Kado, Stanford professor of medicine and geriatrician, joins me to bridge that gap.

From bone health and balance to deprescribing, gut microbiome research, and the surprising power of your attitude towards ageing, this is a masterclass in what actually matters for a long, well-lived life.

What We Cover:

Why "longevity science" is largely gerontology rebranded

A positive attitude towards ageing and its link to lower dementia risk

Balance, power training, and preventing falls and fractures

The truth about osteoporosis medications and the scare that drove millions away

Why extra weight after menopause can be protective

Vitamin D, sleep regularity, and the gut microbiome

This one will change how you think about growing older, whatever your age.

To connect with Dr Deborah Kado, visit her Stanford profile or find her on LinkedIn.

Enjoyed this episode? A rating and review on the Apple Podcast app helps more people find the show.

Want to support the show?

The best way to support the show is to use the products and services offered by our sponsors. To check them out and enjoy great savings, visit theproof.com/friends. You can also support the show by leaving a review on the Apple Podcast app and sharing your favourite episodes with friends and family.

This episode is brought to you by:

38TERA

Consider 38TERA's DMN prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout.

38Tera ships to the United States, Australia, and New Zealand.

ProLon

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ProLon ships within the United States.

SwimClub

SwimClub is a science-backed supplement designed to support male fertility, sperm health, and reproductive wellness. Head to swimclub.co to get 25% off your first order with code THEPROOF.

IM8

With 92 nutrients, including Vitamin B12, Iodine, Selenium and Vitamin D, in highly absorbable forms, IM8 Daily Essentials is the perfect all-in-one daily multi-vitamin to ensure you meet your daily micronutrient needs. IM8 is offering an exclusive 10% off your first order with a free welcome kit when you enter the promo code SIMON at checkout on im8health.com.

IM8 ships to 27 countries including the U.S., Canada, the U.K., Australia, and many regions across Europe, Asia, and South America.

Function Health

Take charge of your health with advanced blood testing and personalised insights. Function Health offers a practical way to track key health markers such as cholesterol, blood sugar, and more. Learn more and join at functionhealth.com/simonhill for a $25 credit toward your membership. Only available to those living in the United States.

Function Health ships to 48 U.S. states, excluding Rhode Island, Hawai‘i, and Puerto Rico.

WHOOP

Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon.

Whoop ships to 56+ international markets, including the US, Canada, most of Europe, Australia, New Zealand, UAE, Singapore, and parts of Asia.

Simon Hill, MSc, BSc (Hons)

Creator of theproof.com

Host of The Proof with Simon Hill

Author of The Proof is in the Plants

Subscribe & Connect:

YouTube

Apple Podcasts

Spotify

Instagram: @simonhill

Twitter: @theproof

Facebook: The Proof with Simon Hill

Nourish your gut with my Plant-Based Ferments Guide and download my Two-Week Meal Plan.

Professor Roy Taylor returns, three years after his first appearance, with the five-year DiRECT trial results and a clear-eyed assessment of where diet-driven type 2 diabetes remission stands in the GLP-1 era.

The evidence is now solid: type 2 diabetes is, for many, a reversible condition of excess fat in the liver and pancreas. But keeping it in remission demands keeping the weight off, and the new generation of weight loss drugs comes with marketing claims that Roy says have no evidence behind them.

What We Cover:

The Twin Cycle Hypothesis and personal fat threshold

Five-year DiRECT data: durable remission, halved hospital admissions, fewer cancers

Why regaining the weight means the diabetes returns

GLP-1s: what they genuinely do, and what's marketing

The muscle loss panic, put in perspective

Gestational diabetes and pre-pregnancy weight

Whether you have type 2 diabetes, care for someone who does, or simply want to understand one of the biggest shifts in modern medicine, this conversation delivers.

To learn more about Professor Roy Taylor's work, visit his research site at Newcastle University or read his book Life Without Diabetes. Clinicians can also explore his type 2 diabetes remission toolkit for general practice.

Enjoyed this episode? A rating and review on the Apple Podcast app helps more people find the show.

Want to support the show?

The best way to support the show is to use the products and services offered by our sponsors. To check them out and enjoy great savings, visit theproof.com/friends. You can also support the show by leaving a review on the Apple Podcast app and sharing your favourite episodes with friends and family.

This episode is brought to you by:

38TERA

Consider 38TERA's DMN prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout.

38Tera ships to the United States, Australia, and New Zealand.

Upwork

Post your job for free at Upwork.com and connect with top talent ready to help your business grow. Find the right talent to support your business and bring your projects to life.

Function Health

Take charge of your health with advanced blood testing and personalised insights. Function Health offers a practical way to track key health markers such as cholesterol, blood sugar, and more. Learn more and join at functionhealth.com/simonhill for a $25 credit toward your membership. Only available to those living in the United States.

Function Health ships to 48 U.S. states, excluding Rhode Island, Hawai‘i, and Puerto Rico.

Momentous

My go-to supplement brand for protein and creatine is Momentous. Use code THEPROOF for up to 35% off your first order at livemomentous.com.

Momentous ships to many countries worldwide depending on local import regulations.

HomeServe

Help protect your home systems – and your wallet – with HomeServe against covered repairs. Plans start at just $4.99 a month. Go to HomeServe.com to find the plan that’s right for you.

HomeServe is not available everywhere. Most plans range between $4.99 to $11.99 a month your first year. Terms apply on covered repairs.

Skylight

Families are better when they’re working together. Right now, Skylight is offering our listeners $30 off their 15 inch Calendars by going to MySkylight.com/THEPROOF.

Skylight ships within the U.S. and to Canada, Australia, and the United Kingdom.

WHOOP

Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon.

Whoop ships to 56+ international markets, including the US, Canada, most of Europe, Australia, New Zealand, UAE, Singapore, and parts of Asia.

Simon Hill, MSc, BSc (Hons)

Creator of theproof.com

Host of The Proof with Simon Hill

Author of The Proof is in the Plants

Subscribe & Connect:

YouTube

Apple Podcasts

Spotify

Instagram: @simonhill

Twitter: @theproof

Facebook: The Proof with Simon Hill

Nourish your gut with my Plant-Based Ferments Guide and download my Two-Week Meal Plan.

Can you meaningfully improve type 2 diabetes without losing weight? Dr Nicola Guess, registered dietitian and Senior Research Fellow at the University of Oxford, says the evidence is clear: a higher-protein, lower-carbohydrate diet can lower post-meal glucose by more than medication, no weight loss required.

We also tackle the noisier end of the blood sugar conversation: glucose spikes, fruit fear, insulin-first theories of obesity, and the panic about GLP-1s and muscle loss.

What We Cover:

Why glucose only causes direct harm at diabetic levels

How protein wakes up "sleepy" beta cells

What overfeeding trials reveal about insulin and obesity

Fruit, fibre, and fat quality: what matters and what doesn't

Menopause, PCOS, and shift work

The truth about GLP-1s and muscle loss

If you want a clear-eyed guide to metabolic health without the hype, this episode delivers.

To connect with Dr Nicola Guess, visit nicolaguess.com or find her on Instagram and YouTube.

Want to support the show?

The best way to support the show is to use the products and services offered by our sponsors. To check them out and enjoy great savings, visit theproof.com/friends. You can also support the show by leaving a review on the Apple Podcast app and sharing your favourite episodes with friends and family.

This episode is brought to you by:

38TERA

Consider 38TERA's DMN prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout.

38Tera ships to the United States, Australia, and New Zealand.

Function Health

Take charge of your health with advanced blood testing and personalised insights. Function Health offers a practical way to track key health markers such as cholesterol, blood sugar, and more. Learn more and join at functionhealth.com/simonhill for a $25 credit toward your membership. Only available to those living in the United States.

Function Health ships to 48 U.S. states, excluding Rhode Island, Hawai‘i, and Puerto Rico.

Shopify

Shopify, the world's leading e-commerce platform, helps you turn browsers into buyers with the internet’s best-converting check out–up to 36% better compared to other leading e-commerce platforms. To boost your conversion rate, and grow your business, sign up for your one-dollar-per-month trial at shopify.com/proof.

Eight Sleep

Upgrade your sleep with the Pod 5 Ultra by Eight Sleep. Clinically validated to deliver up to 1 extra hour of quality sleep per night through temperature control and biometric tracking. Use code THEPROOF at eightsleep.com/theproof for up to $350 off. You get 30 days to try it at home and return it if you don't love it.

Eight Sleep ships to the U.S. (excluding Alaska, Hawaii, and territories), Canada, Mexico, most of the EU, the U.K., Australia, the UAE, Saudi Arabia, and Switzerland.

IM8

With 92 nutrients, including Vitamin B12, Iodine, Selenium and Vitamin D, in highly absorbable forms, IM8 Daily Essentials is the perfect all-in-one daily multi-vitamin to ensure you meet your daily micronutrient needs. IM8 is offering an exclusive 10% off your first order with a free welcome kit when you enter the promo code SIMON at checkout on im8health.com.

IM8 ships to 27 countries including the U.S., Canada, the U.K., Australia, and many regions across Europe, Asia, and South America.

WHOOP

Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon.

Whoop ships to 56+ international markets, including the US, Canada, most of Europe, Australia, New Zealand, UAE, Singapore, and parts of Asia.

Simon Hill, MSc, BSc (Hons)

Creator of theproof.com

Host of The Proof with Simon Hill

Author of The Proof is in the Plants

Subscribe & Connect:

YouTube

Apple Podcasts

Spotify

Instagram: @simonhill

Twitter: @theproof

Facebook: The Proof with Simon Hill

Nourish your gut with my Plant-Based Ferments Guide and download my Two-Week Meal Plan.

About one in seven couples are unable to conceive after a year of trying, and roughly half of those cases involve a male contribution. Yet in a quarter to a third of them, the man is never properly evaluated. In this episode I sit down with Dr Michael Eisenberg, a urologist, Director of Male Reproductive Health at Stanford University and Chief Medical Advisor of SwimClub, and Dr Natalie Crawford, a reproductive endocrinologist and co-founder of Fora Fertility in Austin, Texas.

This is the comprehensive male fertility resource I went looking for and couldn't find, and I have a personal stake in it. What surprised me most is that sperm health appears to be about much more than conception. It tracks with metabolic health, immune health, pregnancy outcomes, and in one Danish cohort, with age of death decades later.

What We Cover

What a semen analysis measures, and why ejaculating normally tells you nothing

Semen quality as a sixth vital sign, and the Danish study linking it to lifespan

Testosterone therapy, why it functions as a contraceptive, and how long recovery takes

Whether sperm counts are really declining, and the likely drivers

Cannabis, alcohol, heat, cycling, sleep, and body weight

Total motile sperm count, DNA fragmentation, and what to ask your lab for

Paternal age, sperm freezing, and timing your decisions

Sperm turn over roughly every three months, which makes this one of the most movable metrics in health. Whichever stage of life you're at, this conversation is worth your time.

To connect with Dr Michael Eisenberg, find him on Instagram or LinkedIn. To connect with Dr Natalie Crawford, you can find her book The Fertility Formula at nataliecrawfordmd.com/book, listen to her podcast As a Woman, or follow her on Instagram, TikTok, YouTube, and LinkedIn.

If this episode was useful, please leave a rating and review on Apple Podcasts. It genuinely helps more people find the show.

Want to support the show?

The best way to support the show is to use the products and services offered by our sponsors. To check them out and enjoy great savings, visit theproof.com/friends. You can also support the show by leaving a review on the Apple Podcast app and sharing your favourite episodes with friends and family.

This episode is brought to you by:

38TERA

Consider 38TERA's DMN prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout.

38Tera ships to the United States, Australia, and New Zealand.

IM8

With 92 nutrients, including Vitamin B12, Iodine, Selenium and Vitamin D, in highly absorbable forms, IM8 Daily Essentials is the perfect all-in-one daily multi-vitamin to ensure you meet your daily micronutrient needs. IM8 is offering an exclusive 10% off your first order with a free welcome kit when you enter the promo code SIMON at checkout on im8health.com.

IM8 ships to 27 countries including the U.S., Canada, the U.K., Australia, and many regions across Europe, Asia, and South America.

Pique

Pique’s Nandaka combines fermented Pu’er tea, full-spectrum Reishi, ceremonial cacao, and L-theanine for calm, sustained energy without the coffee crash. Unlock 20% off and establish your powerful foundation for sustained well-being at Piquelife.com/SIMON.

Pique ships within the U.S. and to Australia, Canada, and select EU countries.

Skylight

Families are better when they’re working together. Right now, Skylight is offering our listeners $30 off their 15 inch Calendars by going to MySkylight.com/THEPROOF.

Skylight ships within the U.S. and to Canada, Australia, and the United Kingdom.

Function Health

Take charge of your health with advanced blood testing and personalised insights. Function Health offers a practical way to track key health markers such as cholesterol, blood sugar, and more. Learn more and join at functionhealth.com/simonhill for a $25 credit toward your membership. Only available to those living in the United States.

Function Health ships to 48 U.S. states, excluding Rhode Island, Hawai‘i, and Puerto Rico.

WHOOP

Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon.

Whoop ships to 56+ international markets, including the US, Canada, most of Europe, Australia, New Zealand, UAE, Singapore, and parts of Asia.

Simon Hill, MSc, BSc (Hons)

Creator of theproof.com

Host of The Proof with Simon Hill

Author of The Proof is in the Plants

Subscribe & Connect:

YouTube

Apple Podcasts

Spotify

Instagram: @simonhill

Twitter: @theproof

Facebook: The Proof with Simon Hill

Nourish your gut with my Plant-Based Ferments Guide and download my Two-Week Meal Plan.

Dr Terry Simpson is back, and we go deep on the science of protecting your heart and brain for the long run. He is a surgeon and one of the clearest voices online for separating solid evidence from confident hype, and in this conversation we tackle everything from new cholesterol-lowering drugs to gene editing, cognitive ageing, and the lean mass hyperresponder debate.

Along the way we get a few things off our chests about the misinformation that spreads faster than the careful answer ever can.

What We Cover

Why healthy ageing brains owe more to lifestyle than to genetics

How PCSK9 inhibitors work, and why plaque is more like geology than plumbing

Gene editing for cholesterol and functional cures for type 1 diabetes

The lean mass hyperresponder debate and what the Keto-CTA re-analysis shows

Why colorectal cancer is rising in younger adults

The 2026 dyslipidemia guidelines and why you should test your Lp(a) once

This is a grounded, evidence-first conversation, and I hope it helps you feel clearer and more confident about the decisions that actually move the needle. If you enjoy the episode, please take a moment to rate and review the show, it genuinely helps more people find it.

To connect with Dr Terry Simpson, visit terrysimpson.com, where you will find his bio, recipes, and plenty more. You can also follow him on Instagram, X, and TikTok, and read his writing on Substack.

Want to support the show?

The best way to support the show is to use the products and services offered by our sponsors. To check them out and enjoy great savings, visit theproof.com/friends. You can also support the show by leaving a review on the Apple Podcast app and sharing your favourite episodes with friends and family.

This episode is brought to you by:

38TERA

Consider 38TERA's DMN prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout.

38Tera ships to the United States, Australia, and New Zealand.

Momentous

My go-to supplement brand for protein and creatine is Momentous. Use code THEPROOF for up to 35% off your first order at livemomentous.com.

Momentous ships to many countries worldwide depending on local import regulations.

Eight Sleep

Upgrade your sleep with the Pod 5 Ultra by Eight Sleep. Clinically validated to deliver up to 1 extra hour of quality sleep per night through temperature control and biometric tracking. Use code THEPROOF at eightsleep.com/theproof for up to $350 off. You get 30 days to try it at home and return it if you don't love it.

Eight Sleep ships to the U.S. (excluding Alaska, Hawaii, and territories), Canada, Mexico, most of the EU, the U.K., Australia, the UAE, Saudi Arabia, and Switzerland.

Function Health

Take charge of your health with advanced blood testing and personalised insights. Function Health offers a practical way to track key health markers such as cholesterol, blood sugar, and more. Learn more and join at functionhealth.com/simonhill for a $25 credit toward your membership. Only available to those living in the United States.

Function Health ships to 48 U.S. states, excluding Rhode Island, Hawai‘i, and Puerto Rico.

LMNT

Stay hydrated with LMNT. Get a free Sample Pack of LMNT’s most popular drink mix flavours with any purchase at DrinkLMNT.com/SIMON Find your favourite LMNT flavour, or share with a friend. And if you don’t like it? Full refund, no questions asked.

LMNT ships to the U.S. and Canada, with sparkling flavors available only in the contiguous U.S.

WHOOP

Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon.

Whoop ships to 56+ international markets, including the US, Canada, most of Europe, Australia, New Zealand, UAE, Singapore, and parts of Asia.

Simon Hill, MSc, BSc (Hons)

Creator of theproof.com

Host of The Proof with Simon Hill

Author of The Proof is in the Plants

Subscribe & Connect:

YouTube

Apple Podcasts

Spotify

Instagram: @simonhill

Twitter: @theproof

Facebook: The Proof with Simon Hill

Nourish your gut with my Plant-Based Ferments Guide and download my Two-Week Meal Plan.