ATTD: Advanced Technologies and Treatments for Diabetes

In this episode of ATTD Diabetes Talks, host Diana Isaacs is joined by Dr. Medha Munshi, Director of the Joslin Geriatric Diabetes Program and Professor of Medicine at Harvard Medical School. Together, they discuss the science behind weekly insulin, patient selection criteria, tailoring therapy to individual needs, and specific considerations for older or medically complex adults.

Key Takeaways:
Criteria & Patient Characteristics for Weekly Insulin

Managing Resistance, Comorbidities & Lifestyle

Benefits for Older Adults & Complex Patients

Individualizing Treatment & Best Practices

You can find more resources on the ATTD Education Portal. Register now to access exclusive content and stay ahead in the field.

This series is supported by Eli Lilly & Company.

In this episode, we explore the science behind weekly insulin, including the pharmacology of weekly insulin, its mechanism of action, how it differs from daily insulin formulations, and why it provides consistent control over a longer period.
Guest: Dr. Manasi Shah, Assistant Professor of Medicine at Eastern Virginia Medical School and Director of the Inpatient Diabetes Program at Sentara Norfolk General Hospital
Key discussion points:
What are the key pharmacokinetic properties that enable once-weekly insulin administration?

How does the pharmacodynamic profile differ from that of daily basal insulin formulations?

What mechanisms allow weekly insulin to provide sustained glucose control over several days?

How does this prolonged action translate into clinical glycemic stability?

What are the key pharmacological considerations clinicians should be aware of when interpreting data on weekly insulin?

What remaining scientific questions need to be addressed before broader clinical adoption?

You can find more resources on the ATTD Education Portal. Register now to access exclusive content and stay ahead in the field.
This series is supported by Eli Lilly & Company

In this inaugural episode of ATTD Diabetes Talks: The Power of Weekly Insulin, we delve into the evolution and future of basal insulin therapy. Host Diana Isaacs sits down with Dr. Rodolfo Galindo to explore the pharmacological innovations behind weekly insulin formulations and discuss how this breakthrough is reshaping modern diabetes management.
Guest: Dr. Rodolfo Galindo (Associate Professor of Medicine and Director of the Comprehensive Diabetes Center at the University of Miami Health System)
Key Topics Covered:
The Evolution of Basal Insulin: A look back at the progression from early long-acting formulations to current weekly treatment options.

Pharmacological Innovation: Understanding the science that makes weekly insulin formulations possible.

Clinical Advantages: Exploring the theoretical benefits of weekly versus daily basal insulin.

Patient Impact: Examining how shifting to a weekly regimen affects treatment burden and overall patient experience.

Future Outlook: How weekly insulin is poised to fit into the broader landscape of diabetes care.

Resources:
For more in-depth knowledge and exclusive content, visit the ATTD Education Portal.

Subscribe to the podcast to stay updated on the latest in diabetes management.

Join host Dr. David Ahn and guest Dr. Michael Haller (Professor and Chief of Pediatric Endocrinology at the University of Florida and Chair of TrialNet) as they take a comprehensive review of the evidence base and remaining gaps for inhaled insulin use in pediatric and adolescent populations
In this final episode, we dive into:
Key Challenges in Pediatrics: Unmet needs in pediatric insulin therapy, including injection fatigue and tech-retention issues for active youth.

The INHALE-1 Study: A deep dive into the randomized controlled trial data of 230 youth, highlighting efficacy, per-protocol non-inferiority, less weight gain, and superior treatment satisfaction among kids and parents.

Safety Profile: Analyzing forced expiratory volume (FEV1) data showing an excellent safety signal with no differences in pulmonary function or severe hypoglycemic events.

Practical Toolkit Use Cases: How the unique pharmacokinetic profile of inhaled insulin provides unmatched benefits for covering adrenaline-rush highs and avoiding hypoglycemia tail effects during sports and exercise.

Dosing Guidelines: Overcoming the practical "paradigm shift" of converting injected units to inhaled units and managing dosing effectively.

Future Horizons: Anticipating the "INHALE FIRST" study investigating early onboarding for newly diagnosed patients and introducing a new two-unit inhaled insulin cartridge.

About ATTD Diabetes Talks:
A podcast series dedicated to providing healthcare professionals with the latest knowledge and best practices in diabetes management, supported by MannKind Corporation.
Find more resources on the ATTD Education Portal: https://unlok-education.com/attd/
Subscribe to the podcast for more updates on advancing diabetes care.
#DiabetesManagement #PediatricEndocrinology #InhaledInsulin #ATTD #DiabetesCare #MedicalPodcast #Type1Diabetes
Chapters:
00:00 Intro and Unique Challenges in Pediatric Diabetes Management
02:38 The INHALE-1 Study: Efficacy, Satisfaction, and Weight Findings
06:27 Safety Signals, Pulmonary Function, and Adherence Challenges
10:18 Practical Toolkit Use Cases: Managing Sports and Exercise
12:48 Dosing Conversions and Practical Patient Selection Guidelines
15:02 Off-Label Integration with Automated Insulin Delivery (AID) Systems
20:14 Caregiver & School Nurse Roles and Managing Safety Concerns
22:00 Research Gaps, The INHALE FIRST Trial, and Wrap Up

Join host Dr. David Ahn and guest Dr. Roy Beck (Founder and Medical Director of the Jaeb Center for Health Research) as they explore the integration of inhaled insulin with automated insulin delivery (AID) systems.
In this episode, we dive into:
The potential of combining inhaled insulin with current AID technologies.

Theoretical advantages, including postprandial management.

Current evidence, clinical considerations, and existing evidence gaps.

Practical insights for clinicians on patient education and system integration.

About ATTD Diabetes Talks:
A podcast series dedicated to providing healthcare professionals with the latest knowledge and best practices in diabetes management, supported by MannKind Corporation.
Find more resources on the ATTD Education Portal: https://unlok-education.com/attd/
Subscribe to the podcast for more updates on advancing diabetes care.
#DiabetesManagement #AIDSystems #InhaledInsulin #ATTD #DiabetesCare #MedicalPodcast #Endocrinology
Chapters:
00:00 Intro
03:03 How Inhaled Insulin Works
07:30 Real World Dosing Workflow
10:24 Exercise and Safety Upside
15:45 Clinician Education Tips
17:38 Research Gaps and Trials Needed
19:32 Future Potential and Wrap Up