ReversABLE

What if understanding gut health requires looking beyond protein, fat, and carbohydrates to the microscopic structures that coat our cells?
In this episode of ReversABLE, Josh Dech welcomes back Dr. Robert Kiltz for a deep dive into the glycocalyx: a sugar-rich layer on the surface of cells that plays important roles in cellular recognition, communication, and interactions with the surrounding environment.
Dr. Kiltz introduces the field of glycobiology and explains glycosylation, the process through which sugars attach to proteins and influence their structure and function. Using accessible analogies, including a biological barcode and an antenna that senses the cellular environment, he explores how these structures help the body distinguish between self and non-self.
The conversation connects this biology to gut health, the intestinal barrier, the microbiome, and immune function. Because the gut encounters an enormous range of substances from the outside environment, understanding its protective mechanisms is relevant to discussions about inflammation and intestinal permeability. Josh and Dr. Kiltz explore the possibility that changes in the glycocalyx may influence how the body interacts with microbes and other foreign substances.
The discussion then moves into a more unconventional examination of human nutrition. Dr. Kiltz challenges conventional assumptions about dietary sugar, energy metabolism, and the relative importance of protein and fat. He discusses adipose tissue as more than stored energy, using the example of hibernating bears to illustrate his perspective on fat as a biological resource.
He also shares his views on raw versus cooked animal foods, rendered fat, and the evolutionary context of human eating patterns.
Some of these nutritional claims are hypotheses and opinions that extend beyond established scientific consensus. This episode is an opportunity to explore the ideas, understand the underlying biology, and distinguish established cellular mechanisms from more speculative interpretations.
If you're interested in gut health, inflammation, the microbiome, cellular biology, and root-cause approaches to chronic illness, this conversation offers a thought-provoking look at a lesser-known area of science — and raises important questions about what we still need to understand about the human body.
 
TOPICS DISCUSSED:
The Glycocalyx And Its Role In Cellular Recognition
Glycosylation And Post-Translational Protein Modification
How Cells Distinguish Between Self And Non-Self
Cellular Electrical Charge And Molecular Communication
The Gut Barrier, Microbiome, And Intestinal Inflammation
Adipose Tissue As A Biological Storage System
Dietary Sugar, Plant Antigens, And Immune Reactions
Raw Versus Cooked Animal Foods And Nutrient Availability
Fat Metabolism, Insulin, And Energy Production
Scientific Paradigms And Gaps In Conventional Nutrition Thinking
 
More from Robert Kiltz:
Website: doctorkiltz.com Instagram: @doctorkiltz
TikTok: @doctorkiltz
Facebook: @doctorkiltz
Youtube: @DrRobLive
 
Leave us a Review:
https://www.reversablepod.com/review
 
Need help with your gut? Visit my website gutsolution.ca to join a program:
Get help now
 
Contact us:
reversablepod.com/tips 
 









FIND ME ON SOCIAL MEDIA:
Instagram 
Facebook 
YouTube

What if your feet play a bigger role in your long-term health than you've been led to believe?
In this episode of ReversABLE, Josh Dech sits down with Mark Sisson, longtime athlete, author of The Primal Blueprint and Born to Walk, and founder of Peluva, to explore the overlooked relationship between foot health, movement, balance, and healthy aging.
Mark argues that modern footwear can restrict natural toe movement and reduce the sensory feedback our feet provide to the brain. He explains how proprioception—the body's ability to sense its position and movement—helps coordinate the kinetic chain, including the ankles, knees, hips, and back. When foot movement is restricted or pain changes the way we walk, other parts of the body may compensate.
Drawing on his own history of athletic injuries, Mark shares why he began rethinking conventional footwear and developed a minimalist shoe designed to provide a wide toe box, a thin sole, flexibility, and greater ground feel. Josh adds a personal perspective, describing how an ankle injury affected his hip mobility and how foot-focused rehabilitation became part of his recovery.
The conversation also explores why Mark considers foot strength an overlooked component of longevity. Balance, reaction time, and the ability to remain physically active become especially important with age. For women concerned about maintaining mobility, strength, and bone density, the discussion highlights how foot discomfort can become a barrier to walking and weight-bearing exercise.
You'll also hear Mark challenge conventional assumptions about heavily cushioned shoes, arch support, and the running boom. He explains why he favors gradual foot conditioning, appropriate footwear, and frequent low-intensity movement over relying exclusively on isolated workouts.
The episode concludes with a practical reminder: walking doesn't need to happen in one long session. Short walks distributed throughout the day can be a useful way to build more movement into everyday life.
If you're interested in root-cause thinking, functional movement, and practical strategies for protecting your mobility, this conversation offers a fresh perspective on a surprisingly overlooked part of the body.
 
TOPICS DISCUSSED:
Foot Anatomy, Proprioception, And The Brain–Body Connection
Modern Footwear, Toe Restriction, And Natural Foot Movement
The Kinetic Chain: How Foot Mechanics Relate To Knees, Hips, And Back
Mark Sisson's Athletic Injuries And The Evolution Of His Footwear Philosophy
Minimalist Shoes And The Development Of Peluva
Foot Strength, Balance, Falls, And Longevity
Bunions, Plantar Fascilitis, Orthotics, And Conventional Podiatry
Walking, Daily Movement, And The Philosophy Behind Born To Walk
Bone Density, Women's Health, And Weight-Bearing Exercise
Barefoot Training, Uneven Terrain, And Practical Foot Conditioning
 
More from Mark Sisson:
Website: peluva.com Instagram: @marksissonprimal
Instagram: @wearpeluva
TikTok: Peluva
Facebook: peluva
Youtube: peluva
Subscribe to Mark Sisson's Newsletter: Mark Sisson's Untethered
Get Mark Sisson's Book: Born To Walk
Get Mark Sisson's Book: The New Primal Blueprint
Get Mark Sisson's Book: Two Meals a Day
Get Mark Sisson's Book: The Primal Kitchen Cookbook
Get Mark Sisson's Book: The Primal Connection
Get Mark Sisson's Book: The Primal Blueprint 21-Day Total Body Transformation
 
Leave us a Review:
https://www.reversablepod.com/review
 
Need help with your gut? Visit my website gutsolution.ca to join a program:
Get help now
 
Contact us:
reversablepod.com/tips 
 









FIND ME ON SOCIAL MEDIA:
Instagram 
Facebook 
YouTube

In this episode of ReversABLE, Josh Dech welcomes back Dr. Nathan S. Bryan, a researcher who has spent 25 years studying nitric oxide and its role in human physiology. Together, they explore how nitric oxide supports vascular function, oxygen delivery, inflammation regulation, and the body's natural repair processes—and why its relationship with chronic illness deserves closer scientific attention.
The conversation begins with an unexpected topic: your mouth. Dr. Bryan discusses the relationship between the oral microbiome, certain mouthwash ingredients, and the body's ability to produce nitric oxide. They examine how oral bacteria participate in the nitrate–nitrite–nitric oxide pathway and why disrupting this process may have implications beyond dental health.
Josh and Nathan then connect nitric oxide to broader questions in functional medicine and root-cause healing. They discuss inflammation, oxidative stress, immune dysfunction, microcirculation, environmental exposures, and the physiological processes involved in delivering oxygen and nutrients to tissues. For listeners navigating chronic gut symptoms or inflammatory conditions, this offers a wider perspective on the systems that interact with the immune system and overall health.
The episode also explores the proposed vascular and metabolic components of Alzheimer's disease, nitric oxide research in stroke recovery, and the potential relationship between nitric oxide signaling and immune-cell behavior. Nathan explains his approach to restorative physiology and why he believes research should focus on the biological mechanisms contributing to disease, rather than only its downstream manifestations.
The conversation becomes more controversial as Josh and Nathan question conventional pharmaceutical incentives, discuss the challenges of funding disruptive research, and share strong opinions about mainstream medical practice and the COVID-19 response. These perspectives are part of the discussion, not proof that the claims made are established scientific consensus.
Finally, Nathan discusses nitric oxide products, the importance of understanding dose and safety, and practical habits he recommends considering, including exercise, nasal breathing, sunlight exposure, and reviewing oral-care choices.
 
TOPICS DISCUSSED:
Nitric Oxide Biology And Its Role In Human Physiology
Chronic Inflammation, Oxidative Stress, And Root-Cause Mechanisms
Alzheimer's Disease, Vascular Health, And Cognitive Function
Oxygen Delivery, Blood Flow, And Hyperbaric Oxygen Therapy
Pharmaceutical Incentives And The Debate Over Symptom Management Versus Root-Cause Treatment
Nitric Oxide Dosing, Supplement Products, And Safety Considerations
Autoimmunity, Macrophage Signaling, And Immune Dysfunction
Environmental Toxicity, Detoxification, And The Body's Natural Repair Processes
The Oral Microbiome, Mouthwash, Fluoride, And Nitric Oxide Production
COVID-19, Respiratory Infections, And Controversial Claims About Disease Prevention
 
More from Dr. Nathan S. Bryan:
Website: n1o1.com Instagram: @drnathansbryan
LinkedIn: Nathan Bryan
Facebook: N1o1 by Pneuma Nitric Oxide
Youtube: Dr Nathan Bryan Nitric Oxide
Get Dr. Nathan S. Bryan's Book: The Secret Of Nitric Oxide
Get Dr. Nathan S. Bryan's Products: n1o1.com/shop
 
Leave us a Review:
https://www.reversablepod.com/review
 
Need help with your gut? Visit my website gutsolution.ca to join a program:
Get help now
 
Contact us:
reversablepod.com/tips 
 









FIND ME ON SOCIAL MEDIA:
Instagram 
Facebook 
YouTube

Dr. Tom O'Bryan returns to ReversABLE for a wide-ranging conversation about gut health, chronic inflammation, the microbiome, environmental toxins, heavy metals, and the deeper mechanisms that may connect digestive dysfunction with systemic and neurological problems.
The conversation begins with LPS, or lipopolysaccharide—a component of the outer membrane of gram-negative bacteria. Tom explains his view that LPS deserves far more attention in discussions around inflammation and describes how increased intestinal permeability may allow inflammatory bacterial components to enter circulation and affect tissues beyond the gut.
Tom then lays out his "perfect storm" framework for chronic inflammatory disease: genetic susceptibility, environmental triggers, dysbiosis, intestinal permeability, and chronic systemic inflammation. Rather than searching for one isolated root cause, he argues that practitioners should look at the entire chain of factors contributing to a person's symptoms and ask what the immune system may be responding to.
The discussion moves into gluten and wheat, including Tom's controversial position that someone can have an immune response to wheat without experiencing obvious digestive symptoms. The episode also explores the relationship between intestinal and other epithelial barriers, including the blood-brain barrier and reproductive tissues.
From there, Josh and Tom explore chemical exposure, heavy metals, fertility, sperm DNA fragmentation, air pollution, and the challenges of interpreting heavy-metal testing. They also discuss why aggressive detoxification can be problematic and why Tom emphasizes reducing ongoing exposure rather than simply pursuing increasingly aggressive detox protocols.
Finally, Tom brings the conversation back to something much more practical: education and incremental change. His "one hour a week" principle is about making small, sustainable changes to reduce environmental and lifestyle stressors over time rather than searching for a single magic intervention.
For anyone interested in gut health, inflammation, the microbiome, immune system regulation, environmental toxins, or a root-cause approach to chronic illness, this episode offers a provocative framework for thinking differently about why the body becomes sick—and what may actually help.
 
TOPICS DISCUSSED:
LPS, Leaky Gut, And Systemic Inflammation
The Five-Part "Perfect Storm" Of Chronic Disease
Gluten, Wheat, And Immune System Activation
Heavy Metals And Total Toxic Burden
Environmental Chemicals And Everyday Toxin Exposure
Brain Inflammation, LPS, And Alzheimer's-Related Mechanisms
Fertility, Sperm DNA Fragmentation, And Paternal Toxicity
Testing For Heavy Metals, Toxins, And Immune Responses
Air Pollution, Children's Brain Health, And Generational Exposure
The One-Hour-A-Week Approach To Incremental Health Change
 
More from Dr. Tom O'Bryan:
Website: thedr.com Instagram: @thedrtomobryan
X: @theDr_com
Facebook: TheDr.Com
Youtube: theDr.com
House Plants That Absorb Toxins In The Air: thedr.com/plants
Get Dr. Tom O'Bryan's Book: You Can Fix Your Brain
Get Dr. Tom O'Bryan's Book: Autoimmune Fix
 
Leave us a Review:
https://www.reversablepod.com/review
 
Need help with your gut? Visit my website gutsolution.ca to join a program:
Get help now
 
Contact us:
reversablepod.com/tips 
 









FIND ME ON SOCIAL MEDIA:
Instagram 
Facebook 
YouTube

What if modern veterinary care is treating the symptoms of chronic disease without addressing the conditions that created them?
In this episode of ReversABLE, Josh Dech sits down with veterinarian Dr. Judy Morgan for a wide-ranging conversation about root-cause pet health, gut health, nutrition, inflammation, the microbiome, immune function, and the growing role of holistic veterinary medicine.
Dr. Morgan shares more than four decades of veterinary experience and explains why she believes pet health has changed dramatically over the past several decades. She discusses the three issues at the center of her work: what she describes as over-vaccination, ultra-processed pet food, and overuse of medications and pesticides.
The conversation then moves into one of the most important foundations of health: nutrition. Dr. Morgan explains her approach to whole-food diets for dogs and cats, why she favors minimally processed ingredients, and how she approaches dietary changes in rescue animals and pets dealing with allergies or digestive problems.
Josh and Judy also explore the connection between lifestyle and the microbiome. Judy describes an informal comparison involving her indoor and outdoor cats and discusses differences she observed in their microbiome profiles, while emphasizing the potential importance of sunlight, soil exposure, fresh plants, movement, hunting behaviors, and environmental enrichment.
The episode also tackles controversial territory, including vaccination schedules, titers, homeopathic nosodes, pharmaceutical companies, corporate ownership of veterinary clinics, prescription diets, flea and tick medications, and the economics influencing veterinary recommendations.
For pet parents dealing with chronic allergies, digestive problems, inflammation, behavioral issues, or recurring health problems, this episode offers a broader framework for thinking about animal health: look beyond the isolated symptom and consider the animal's food, environment, behavior, microbiome, immune system, and overall lifestyle.
 
TOPICS DISCUSSED:
Vaccination Schedules, Titers, And Over-Vaccination
Pet Nutrition, Raw Feeding, And Ultra-Processed Kibble
Corporate Veterinary Medicine, Private Equity, And Pharmaceutical Influence
Whole-Animal Health And Root-Cause Veterinary Care
Pet Allergies, Chronic Inflammation, And The Microbiome
Animal Lifestyle, Stress, Behavior, And Environmental Enrichment
Chinese Veterinary Medicine And Herbal Approaches
Pet Longevity, Rescue Animals, And Disease Prevention
Food Production, Farming, And Reconnecting People With Food
Holistic Veterinary Business, Education, And Naturally Healthy Pets
 
More from Dr. Judy Morgan:
Website: naturallyhealthypets.com Instagram: @drjudymorgan
TikTok: Naturally Healthy Pets
Facebook: Dr. Judy Morgan's Naturally Healthy Pets
Youtube: Dr. Judy Morgan's Naturally Healthy Pets
Listen to Dr. Judy Morgan's Podcast: The Naturally Healthy Pets Podcast
 
Leave us a Review:
https://www.reversablepod.com/review
 
Need help with your gut? Visit my website gutsolution.ca to join a program:
Get help now
 
Contact us:
reversablepod.com/tips 
 









FIND ME ON SOCIAL MEDIA:
Instagram 
Facebook 
YouTube